Results 291 to 300 of about 511,468 (345)

Advanced [18F]FDG and [11C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis

, 2014
J. Yankam Njiwa, Katherine R. Gray, Nicolas Costes, François Mauguı̀ere, Philippe Ryvlin, Alexander Hammers   +5 more
openalex   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Enviromimetics: From exercise mimetics to cognitomimetics in the quest for enhanced brain health and cognition

The Journal of Physiology, EarlyView.
Abstract figure legend A schematic diagram outlining the concept of enviromimetics, and the subclasses of exercise mimetics, epimimetics and cognitomimetics. The rationale is that environmental stimulation and lifestyle factors, including physical activity and cognitive stimulation, have shown beneficial effects across a range of human conditions ...
Anthony J. Hannan
wiley   +1 more source

Targeting necroptosis protects against astrocyte death and hippocampal sclerosis in experimental temporal lobe epilepsy

The Journal of Physiology, EarlyView.
Abstract figure legend Experimentally induced status epilepticus induces microglial TNFα release, which binds to astrocytic TNFR1 and triggers activation of RIPK1/RIPK3/MLKL signalling, initiating necroptotic astrocytic death that contributes to the development of hippocampal sclerosis. Created with Biorender.com.
Zhou Wu, Lukas Henning, Christian Steinhäuser, Peter Bedner   +3 more
wiley   +1 more source

LGI1 encephalitis: potentially complement-activating anti-LGI1-IgG subclasses 1/2/3 are associated with the development of hippocampal sclerosis. [PDF]

J Neurol
Bien CG, Rada A, Mertens M, Bien CI, Bauer J, Hagemann A, Woermann FG.   +6 more
europepmc   +1 more source

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

Glia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips, Emily G. Thompson, Olivia Spead, Balaji G. Vijayakumar, Erica R. Kent, Sean J. Miller, Treasure Nwokeleme, Svetlana Vidensky, Mohamed Hassan Farah, Jeffrey D. Rothstein   +9 more
wiley   +1 more source

Differences and potential mechanisms of theta oscillation and temporoparietal and temporal-central networks in temporal lobe epilepsy patients with unilateral hippocampal sclerosis. [PDF]

Acta Epileptol
Qiu C, Zhong C, Liu Y, Wang L, Tang Y, Liu Z, Guo S, Jiang Y, Li E, Lu J, Yan B, Hao X, Zhou D.   +12 more
europepmc   +1 more source

Scalable spokes pTx pulses for 2D turbo‐spin‐echo imaging at 7 T

Magnetic Resonance in Medicine, Volume 95, Issue 2, Page 740-755, February 2026.
Abstract Purpose Turbo spin echo (TSE) is important clinically. Unfortunately, 7 T TSE suffers from B1+‐induced signal dropouts. Magnitude‐based parallel transmit (pTx) pulse design algorithms cannot enforce phase patterns complying with the Carr‐Purcell‐Meiboom‐Gill conditions (90° phase shift between excitation and refocusing).
Minghao Zhang, Christopher T. Rodgers
wiley   +1 more source

Astrocytic Igfbp2 Promotes Spontaneous Seizures in a Mouse Model of Mesial Temporal Lobe Epilepsy

Glia, Volume 74, Issue 1, January 2026.
Igfbp2 is upregulated in hippocampal astrocytes of MTLE model mice. Igfbp2 enhances dentate granule cell excitability. Astrocytic Igfbp2 deletion reduces spontaneous seizures. ABSTRACT Mesial temporal lobe epilepsy (MTLE) is a common, frequently drug‐resistant epilepsy characterized by seizures arising from the hippocampus.
Shinichi Kinoshita, Nobuyoshi Matsumoto, Shota Morikawa, Yuji Ikegaya, Ryuta Koyama   +4 more
wiley   +1 more source