Results 301 to 310 of about 81,056 (343)

Hippocampal sclerosis without detectable hippocampal atrophy

Neurology, 1994
Six patients from three centers had MRI and pathologic evidence of hippocampal sclerosis but no detectable hippocampal atrophy. Loss of normal internal structure and T1- and T2-weighted signal abnormalities allowed the MRI diagnosis of unilateral hippocampal sclerosis when hippocampal volume measurements were normal and symmetric.
G D, Jackson, R I, Kuzniecky, G D, Cascino   +2 more
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Hippocampal Sclerosis

2019
Abstract Temporal lobe epilepsy (TLE) is the most common form of adult localization-related epilepsy and 80% of these cases originate in the hippocampus. Hippocampal sclerosis (HS) is the single most common cause of medically refractory epilepsy that is also amenable to surgery and is a combination of astrogliosis and atrophy throughout ...
Zoe E. Teton, Ahmed M. Raslan
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Hippocampal sclerosis

Neurology, 2007
Temporal lobe epilepsy is the most commonly encountered partial epilepsy syndrome in adults. Many patients are refractory to medications and therefore considered for surgical treatment. Pathologic series and modern imaging demonstrate evidence of hippocampal (mesial temporal) sclerosis (HS), characterized by cell loss in the hippocampal pyramidal cell ...
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Update on Hippocampal Sclerosis

Current Neurology and Neuroscience Reports, 2015
The diagnostic hallmarks of hippocampal sclerosis (HS) are severe volume loss of the hippocampus, severe neuronal loss, and reactive gliosis involving primarily two especially vulnerable fields, CA1 and the subiculum. Occasionally, HS may be the only neuropathological change detected in older individuals with dementia and is known as pure HS.
Juliana R, Dutra, Etty P, Cortés, Jean Paul G, Vonsattel   +2 more
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Tuberous sclerosis complex coexistent with hippocampal sclerosis

Journal of Clinical Neuroscience, 2016
Tuberous sclerosis and hippocampal sclerosis are both well-defined entities associated with medically intractable epilepsy. To our knowledge, there has been only one prior case of these two pathologies being co-existent. We report a 7-month-old boy who presented with intractable seizures at 2 months of age. MRI studies showed diffuse volume loss in the
Min, Lang, Richard A, Prayson
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Beyond hippocampal sclerosis

Neurology, 2009
Hippocampal atrophy is now routinely detected in MRI studies of patients at the onset of seizures and during presurgical evaluation for intractable temporal lobe epilepsy (TLE). The classic lesion of hippocampal sclerosis (HS) was described in 1880 by Sommer.
Megan Madden, Thomas Sutula
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Hippocampal sclerosis dementia

Neurology, 2004
Rarely considered in the differential diagnosis of dementia, even by cognitive specialists, hippocampal sclerosis (HS) may be the primary cause of dementia (HSD) when it occurs in the elderly population. The articles by Blass et al.1 and Hatanpaa et al.2 in this issue of Neurology characterize clinical and neuropathologic features from a series of HSD ...
Carol F. Lippa, Dennis W. Dickson
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Neuropathology of Hippocampal Sclerosis

2008
Publisher Summary This chapter emphasizes that hippocampal sclerosis (HS), which is a selective neuronal loss and gliosis in the CA1 sector and the subiculum, is often observed in the elderly at the post mortem examination. In many patients who present with dementia, HS coexists with various other types of pathologies, including Alzheimer's disease ...
Catalina, Amador-Ortiz, Dennis W, Dickson   +1 more
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Hippocampus, hippocampal sclerosis and epilepsy

Pharmacological Reports, 2013
Hippocampal sclerosis (HS) is considered one of the major pathogenic factors of drug-resistant temporal lobe epilepsy. HS is characterized by selective loss of pyramidal neurons - especially of sectors CA1 and CA3 of the hippocampus - pathological proliferation of interneuron networks, and severe glia reaction. These changes occur in the course of long-
Sendrowski, Krzysztof, Sobaniec, Wojciech   +1 more
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Epilepsies associated with hippocampal sclerosis

Acta Neuropathologica, 2014
Hippocampal sclerosis (HS) is considered the most frequent neuropathological finding in patients with mesial temporal lobe epilepsy (MTLE). Hippocampal specimens of pharmacoresistant MTLE patients that underwent epilepsy surgery for seizure control reveal the characteristic pattern of segmental neuronal cell loss and concomitant astrogliosis.
Fernando, Cendes, Americo C, Sakamoto, Roberto, Spreafico, William, Bingaman, Albert J, Becker   +4 more
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