Results 301 to 310 of about 511,468 (345)

Postsurgical Outcomes of Mesial Temporal Lobe Epilepsy due to Hippocampal Sclerosis Associated with Calcified Neurocysticercosis. [PDF]

Am J Trop Med Hyg
De la Cruz W, Sánchez-Boluarte SS, Chacón DE, Herrera M, Núñez Del Prado L, Vásquez CM, Delgado JC.   +6 more
europepmc   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Have We Solved the Chicken-and-Egg Conundrum? Hippocampal Sclerosis and Temporal Lobe Epilepsy Following Febrile Status Epilepticus: Results of the 10-Year Follow-up FEBSTAT Study. [PDF]

Epilepsy Curr
Feyissa AM.
europepmc   +1 more source

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, Volume 12, Issue 45, December 4, 2025.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

Identification of Six Potential Therapeutic Targets Common to Ischemic Stroke and Vascular Dementia: Genetic Insights From an Integrated Bioinformatics Analysis

Brain and Behavior, Volume 15, Issue 12, December 2025.
This graphical abstract summarizes a multi‐layered analytical framework integrating cis‐eQTLs, UKB‐PPP proteomics, and multivariable Mendelian randomization to dissect the causal links between circulating proteins, vascular risk factors, ischemic stroke (IS), and vascular dementia (VD).
Jian Lyu, Fa Lin, Yi Liu, Yan Chai, Xiaolin Chen, Min Wang, Fumei Liu, Haiyan Xiao, Guibo Sun, Yanming Xie   +9 more
wiley   +1 more source

The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure

Chronic Diseases and Translational Medicine, Volume 11, Issue 4, Page 251-268, December 2025.
The influence of gut microbiota on brain health ABSTRACT Diet provides essential metals, which are required for the growth, development, and well‐functioning of the body. Nonetheless, some natural and human activities add toxic heavy metals to the diet, consequently introducing them to our bodies, resulting in several disorders and death. The intestine,
Luqi Cao, Saurabh Kumar Jha, Neha Gupta, Xiang Chen, Renuka Soni, Luoxi Yuan, Rashi Srivastava, Zhe‐Sheng Chen   +7 more
wiley   +1 more source

Hippocampal sclerosis is associated with celiac disease type immunity in patients with drug-resistant temporal lobe epilepsy. [PDF]

J Neurol
Peltola M, Kaukinen K, Basnyat P, Raitanen J, Haimila K, Liimatainen S, Rainesalo S, Peltola J.   +7 more
europepmc   +1 more source

Surgical treatment may improve depressive and hysterical traits in temporal lobe epilepsy with hippocampal sclerosis: Study using the Minnesota Multiphasic Personality Inventory. [PDF]

PCN Rep
Otabe H, Taniguchi G, Iijima K, Iwasaki M.   +3 more
europepmc   +1 more source

A Morphological Study of Synaptic Reorganization in Mossy Fibers of the Dentate Gyrus according to Hippocampal Sclerosis in Temporal Lobe Epilepsy: A Comparison of Intraoperative ECoG Findings for Tailored Resection.

, 1997
Son Ei, Kim Sp, Kim Im, I H Kim
openalex   +1 more source