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Harm Reduction Journal, 2021 Background The COVID-19 pandemic has had especially devastating effects on people who use drugs. Due to pandemic protocols in the USA, medication-assisted treatment (MAT) regulations became more flexible, permitting our community-based nonprofit ...
Ellis Jaewon Yeo +7 more
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Frontiers in Bioengineering and Biotechnology, 2021 The deposition of pre-metered doses (i.e., defined before and not after exposition) at the air–liquid interface of viable pulmonary epithelial cells remains an important but challenging task for developing aerosol medicines.
Justus C. Horstmann +9 more
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eLife, 2013 by Emma Pewsey (University of Cambridge, UK) Winner of Access to Understanding 2013 X-rays can now be used not only to show where bones have fractured, but also to investigate why these bones break in the first place.
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Mechanisms of non-coding RNA-modulated alternative splicing in cancer
RNA Biology, 2022 Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions.
Xiaolin Wang +6 more
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In vivo and in vitro reconstitution of unique key steps in cystobactamid antibiotic biosynthesis
Nature Communications, 2021 The biosynthetic pathway leading to the production of cystobactamids, a group of myxobacteria-derived topoisomerase inhibitors with potent anti-Gram-negative activity, remains unclear.
Sebastian Groß +4 more
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Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems
Pharmaceutics, 2021 Co-delivery of different species of protein-encoding polynucleotides, e.g., messenger RNA (mRNA) and plasmid DNA (pDNA), using the same nanocarrier is an interesting topic that remains scarcely researched in the field of nucleic acid delivery.
Sarah S. Nasr +5 more
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Pharmaceutics, 2021 Liposomes have been studied for decades as nanoparticulate drug delivery systems for cytostatics, and more recently, for antibiotics. Such nanoantibiotics show improved antibacterial efficacy compared to the free drug and can be effective despite ...
Menka Drost +8 more
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Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms
Pharmaceutics, 2020 The search for novel therapeutics against pulmonary infections, in particular Pseudomonas aeruginosa (PA) biofilm infections, has been intense to deal with the emergent rise of antimicrobial resistance. Despite the numerous achievements in drug discovery
Duy-Khiet Ho +4 more
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Pharmaceuticals, 2021 Non-mammalian in vivo disease models are particularly popular in early drug discovery. Zebrafish (Danio rerio) is an attractive vertebrate model, the success of which is driven by several advantages, such as the optical transparency of larvae, the small ...
Sari Rasheed +3 more
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The co-pyrolysis of flame retarded high impact polystyrene and polyolefins [PDF]
, 2007 The co-pyrolysis of brominated high impact polystyrene (Br-HIPS) with polyolefins using a fixed bed reactor has been investigated, in particular, the effect that different types brominated aryl compounds and antimony trioxide have on the pyrolysis ...
Bhaskar, T. +5 more
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