Results 161 to 170 of about 220,074 (311)

3D‐Printing Aided Rapid Prototyping of Pretensioned Tensegrity Structures for Robotic Applications

Advanced Robotics Research, EarlyView.
Printing, injection molding, and assembly (PMA) is a method for rapid prototyping mesoscale, topologically complex, and tensioned tensegrity structures. In combination with PMA method, two mold design strategies: modular mold and compact channel layout, enable efficiency and scalability for tensegrity fabrication.
Yi Sun, Jan Petrš, Omar Aloui, Dario Floreano   +3 more
wiley   +1 more source

Outcomes of hip reconstruction in ambulatory patients with cerebral palsy and spastic hip displacement: a retrospective study of 73 hips in 55 consecutive patients. [PDF]

Acta Orthop
Park KH, Park BK, Rhee I, Park KB, Park H, Roh YH, Kim HW.   +6 more
europepmc   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Natural History of Nonoperatively Treated Borderline Acetabular Dysplasia in Young Adults and Factors Associated With Inferior Functional Outcome. [PDF]

Orthop J Sports Med
Dimitriou D, Marcus R, Kaiser D, Hoch A, Zingg P.   +4 more
europepmc   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Development and implementation of an interdisciplinary one-stop clinic for infant hip dysplasia: A pilot study. [PDF]

Clinics (Sao Paulo)
Moreno Grangeiro P, Motta GB, Rodrigues NVM, Liggio DF, Bertoldi CA, Coimbra R, Zürcher IF, Herrera YEG, de Freitas Laurentino M, Suzuki L, Calil VT, Montenegro NB, Cerri GG, de Barros Filho TEP, de Carvalho WB, Guarniero R.   +15 more
europepmc   +1 more source

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

Advanced Science, EarlyView.
Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih, Nicolas L.A. Dumaire, Clémence Gieré, Erin Vest, Haya Alkhateeb, Christian P. Moritz, Yannick Tholance, Jean‐Philippe Camdessanché, Jean‐Christophe Antoine, Jérôme Honnorat, Jafar Kafaie, Liberty François‐Moutal, Aubin Moutal   +12 more
wiley   +1 more source

Severe pincer morphology is associated with incident hip osteoarthritis: prospective individual participant data from 18 935 hips from the World COACH consortium. [PDF]

Br J Sports Med
Riedstra N, Boel F, van Buuren MM, Ahedi H, Arbabi V, Arden NK, Baart SJ, Bierma-Zeinstra SMA, Cicutini F, Cootes T, Crossley KM, Felson DT, Gielis WP, Heerey JJ, Jones G, Kluzek S, Lane NE, Lindner C, Lynch JA, van Meurs J, Mosler AB, Nelson AE, Nevitt MC, Oei EHG, Runhaar J, Tang J, Weinans H, Agricola R.   +27 more
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Super-resolution ultrasound imaging reveals microvascular alterations in joint capsule of dysplastic hip: a rabbit model study. [PDF]

BMC Musculoskelet Disord
Wan J, Qiao Y, Lv P, Hong K, Ye L, Wang J, Zhang C.   +6 more
europepmc   +1 more source