Results 41 to 50 of about 4,848,621 (165)

Elevated Nocturnal CO2 and Autonomic Dysfunction in Children With Down Syndrome

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Sleep‐disordered breathing (SDB) frequently complicates Down syndrome (DS). Beyond upper airway obstruction, emerging evidence suggests an autonomic nervous system (ANS) dysfunction affecting CO2 regulation. The aim of this study was to investigate nocturnal gas exchanges in children with DS and compare them to what has been ...
Jessica Taytard, Segolène Falquero, Sophie Denamur, Pierre‐Yves Boelle, Karl Leroux, Harriet Corvol, Aimé Ravel, Clotilde Mircher, Jeanne Toulas, Emmanuelle Prioux, Marie‐Anne Caillaud, Guillaume Aubertin, Hervé Walti   +12 more
wiley   +1 more source

TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour

The Journal of Physiology, EarlyView.
Abstract figure legend TMEM16A plays a pivotal role in setting the duration of the action potential plateau in human uterine smooth muscle. An increase in TMEM16A expression in labour underpins a lengthening of the plateau and this provides time for the contraction to become larger and longer, important for timely successful labour.
Helena C. Parkington, Harold A. Coleman, Penelope M. Sheehan, Shaun P. Brennecke, Marianne Tare   +4 more
wiley   +1 more source

Third Space Endoscopic Therapies for Benign Motility Disorders: A Narrative Review

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objectives To review the evidence base, evolution, outcomes, adverse events (AEs), and management for third‐space endoscopy (TSE) procedures for management of benign motility disorders. Methods This review examines TSE procedures for motility disorders, reviewing the current available techniques, success, outcomes, and long‐term outcomes from ...
Sanjana Bhagwat, Amol Bapaye
wiley   +1 more source

Hirschsprung Disease

, 2020
© 2020, Springer Nature Switzerland AG. Purpose of review: Hirschsprung disease is an uncommon congenital disorder in which the ganglion cells are missing in the distal colon, resulting in functional obstruction.
Langer, Jacob C., Levitt, Marc A.
core   +1 more source

High-resolution anorectal manometry in children [PDF]

Clinical and Experimental Pediatrics
Anorectal manometry is one of the motility tests in children performed by pediatric gastroenterologist. It evaluates the motility function of anorectal tract.
Yogesh Waikar
doaj   +1 more source

Total colonic aganglionosis and cleft palate in a newborn with Janus-cysteine 618 mutation of RET proto-oncogene: a case report

Italian Journal of Pediatrics, 2020
Background Hirschsprung disease, the most important congenital colonic dysmotility in children results from neural crest migration, differentiation, proliferation, or apoptosis defects where the rearranged during transfection (RET)-Protooncogene pathway ...
Ingrid Anne Mandy Schierz, Marcello Cimador, Mario Giuffrè, Claudia Maria Aiello, Vincenzo Antona, Giovanni Corsello, Ettore Piro   +6 more
doaj   +1 more source

Recurrent Congenital Hiatal Hernia After Laparoscopic Repair Complicated by Gastric Perforation and Abdominal Compartment Syndrome

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Complete excision of the hernial sac during congenital hiatal hernia repair may help prevent recurrence. This case also emphasizes the importance of early recognition and prompt management of abdominal compartment syndrome when progressive abdominal distension and organ dysfunction develop postoperatively.
Takayuki Fujii, Yui Noguchi, Nanami Harada, Hiroto Katami, Aya Tanaka   +4 more
wiley   +1 more source

The frequency and characteristics of inflammatory bowel disease in pediatric patients with Hirschsprung's disease: A case-control study

Gastroenterology & Endoscopy
Background: Hirschsprung disease is associated with enterocolitis and inflammatory bowel disease (IBD) as it affects bowel innervation from birth. This study is about the evaluation of IBD in children with diagnosed Hirschsprung disease.
Naghi Dara, Niloofar Ziba, Leily Mohajerzadeh, Yasaman Zarinfar, Arshia Dara, Amirhossein Hosseini, Saleheh Tajalli, Nathalia Sernizon Guimarães, Mohammadreza Esmaeili Dooki, Mahmoud Hajipour, Farid Imanzadeh   +10 more
doaj   +1 more source

Adult Onset Hirschsprung's Disease With Overlapping Presentation of Sigmoid Volvulus: Two Case Reports With Literature Review at Tikur Ambessa Specialized Hospital, AAU, Ethiopia

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Adult‐onset Hirschsprung's disease (HSD) is uncommon and frequently leads to diagnostic difficulty after infancy. It is a congenital illness that causes intestinal obstruction due to a lack of ganglion cells. Approximately 1 in 5000 live newborns have this illness, and 95% of HSD cases are identified in infants.
Abel shiferaw Tesfaye, Samson Yadeta Murre, Mikiyas Olani Kebede, Isa Salo Abdo, Mulugeta Temesgen Bonger, Abel Daniel Kuche   +5 more
wiley   +1 more source

Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis

Microorganisms, 2021
Hirschsprung-associated enterocolitis (HAEC) is a common life-threatening complication of Hirschsprung disease (HSCR). It has been proposed that gut microbiota, which have an essential role in gut-homeostasis, are associated with HAEC.
Sireekarn Chantakhow, Jiraporn Khorana, Kanokkan Tepmalai, Nonglak Boonchooduang, Nipon Chattipakorn, Siriporn C. Chattipakorn   +5 more
doaj   +1 more source