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Seminars in Pediatric Surgery, 2008
Hirschsprung disease is a relatively common condition managed by pediatric surgeons. Significant advances have been made in understanding its etiologies in the last decade, especially with the explosion of molecular genetic techniques and early diagnosis. The surgical management has progressed from a two- or three-stage procedure to a primary operation.
Ramanath N, Haricharan +1 more
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Hirschsprung disease is a relatively common condition managed by pediatric surgeons. Significant advances have been made in understanding its etiologies in the last decade, especially with the explosion of molecular genetic techniques and early diagnosis. The surgical management has progressed from a two- or three-stage procedure to a primary operation.
Ramanath N, Haricharan +1 more
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Current Opinion in Pediatrics, 2010
Hirschsprung disease is relatively common in children. Surgical techniques are available to remove the aganglionic bowel and reconstruct the intestinal tract. Despite many advances, these children may still be difficult to diagnose, and may have ongoing functional problems after surgical correction.The genetic basis and cause of Hirschsprung disease ...
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Hirschsprung disease is relatively common in children. Surgical techniques are available to remove the aganglionic bowel and reconstruct the intestinal tract. Despite many advances, these children may still be difficult to diagnose, and may have ongoing functional problems after surgical correction.The genetic basis and cause of Hirschsprung disease ...
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Surgical Clinics of North America, 1985
This review of Hirschsprung's disease reflects the authors' experience with it and outlines the current recommendations for management of its various manifestations.
L W, Martin, A M, Torres
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This review of Hirschsprung's disease reflects the authors' experience with it and outlines the current recommendations for management of its various manifestations.
L W, Martin, A M, Torres
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BMJ, 2012
A 3 year old boy is brought to his general practitioner again by his worried mother. She is concerned that he remains constipated despite trying a third different laxative. Further history showed that he passed his first meconium only on day 5, and since then has been opening his bowels only weekly, with associated straining. His growth has fallen from
A, Arshad, C, Powell, M P, Tighe
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A 3 year old boy is brought to his general practitioner again by his worried mother. She is concerned that he remains constipated despite trying a third different laxative. Further history showed that he passed his first meconium only on day 5, and since then has been opening his bowels only weekly, with associated straining. His growth has fallen from
A, Arshad, C, Powell, M P, Tighe
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Current Treatment Options in Gastroenterology, 2003
Hirschsprung's disease (HSCR) is the most common congenital malformation of the enteric nervous system and requires early diagnosis and surgical repair for the best comprehensive outcome. The early diagnosis of this disorder permits the use of primary endorectal pull-through (PERPT), which is now the definitive surgical therapy for HSCR.
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Hirschsprung's disease (HSCR) is the most common congenital malformation of the enteric nervous system and requires early diagnosis and surgical repair for the best comprehensive outcome. The early diagnosis of this disorder permits the use of primary endorectal pull-through (PERPT), which is now the definitive surgical therapy for HSCR.
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Genetics of Hirschsprung disease
Current Opinion in Pediatrics, 2000Hirschsprung disease (HSCR), or congenital intestinal aganglionosis, is a relatively common disorder of neural crest migration. It has a strong genetic basis, although simple Mendelian inheritance is rarely observed. Hirschsprung disease is associated with several other anomalies and syndromes, and animal models for these conditions exist. Mutations in
M A, Parisi, R P, Kapur
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The genetics of Hirschsprung disease
Gastroenterology Clinics of North America, 2003Understanding the genetics of Hirschsprung disease will naturally expand our understanding of other neurocristopathies, the enteric nervous system, and autonomic system biology. As other disorders of gastrointestinal motility are investigated, genetics may resolve certain clinical questions.
Douglas R, Stewart, Daniel, von Allmen
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Hirschsprung's Disease in the Newborn
Archives of Surgery, 1959Hirschsprung's disease is one of the more frequent causes of intestinal obstruction in the newborn. Improvements in the methods of diagnosis and management of patients in this group have increased the survival rate. The 3-day-old infant in Figure 1 has the signs of acute intestinal obstruction.
O, SWENSON, J H, FISHER
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Surgical Clinics of North America, 1976
Hirschsprung's disease or aganglionic megacolon is an anomaly caused by the absence of ganglion cells in the myenteric plexus of the distal colon. It produces intestinal obstruction or lethal enterocolitis in the neonatal period and constipation of varying degree in the older child.
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Hirschsprung's disease or aganglionic megacolon is an anomaly caused by the absence of ganglion cells in the myenteric plexus of the distal colon. It produces intestinal obstruction or lethal enterocolitis in the neonatal period and constipation of varying degree in the older child.
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Hirschsprung's Disease in Infants
Archives of Surgery, 1959Introduction Until recently, the clinical course of aganglionic megacolon was considered to be of a chronic and protracted nature with obstipation as the presenting symptom. In the past few years, however, several excellent papers have appeared by Dorman 1 and Sieber and Girdany 2 in which the severe and fulminating course of symptomatic Hirschsprung ...
T C, JEWETT, L J, LEAHY, J, LANIGAN
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