Results 201 to 210 of about 53,297 (369)
Advanced Science, EarlyView.Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao +4 more
wiley +1 more source
Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming
Advanced Science, EarlyView.Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu +13 more
wiley +1 more source
His bundle pacing in nodal versus infranodal atrioventricular block: a mid-term follow-up study. [PDF]
Open Heart, 2023 Pestrea C +4 more
europepmc +1 more source
Advanced Science, EarlyView.A minimal computational model of cellular aggregate formation in neurodegenerative disease, encompassing two competing processes: cell‐autonomous and cell‐to‐cell triggers of aggregation, is presented. Despite its simplicity, the model can reproduce the aggregate patterns observed in post‐mortem brain images from the primary tauopathy Progressive ...
Shih‐Huan Huang +8 more
wiley +1 more source
Anatomical Considerations for His Bundle Pacing [PDF]
Circulation: Arrhythmia and Electrophysiology, 2019 Venkat D, Nagarajan +2 more
openaire +2 more sources
Advanced Science, EarlyView.The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu +10 more
wiley +1 more source