Results 211 to 220 of about 774,959 (291)

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

Environmental pollutant risk factors for worse COVID-19 related clinical outcomes in predominately hispanic and latino populations. [PDF]

Environ Res
Baumert BO, Wang H, Samy S, Park SK, Lam CN, Dunn K, Pinto-Pacheco B, Walker D, Landero J, Conti D, Chatzi L, Hu H, Goodrich JA.   +12 more
europepmc   +1 more source

Absorption, distribution, metabolism and excretion of londamocitinib after single‐dose inhaled, intravenous and oral administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim Londamocitinib (AZD4604) is an inhaled, selective Janus kinase 1 (JAK1) inhibitor in development for asthma. This open‐label, two‐part, phase I clinical study (NCT06157255) used a radiolabelled microtracer approach to evaluate the absolute bioavailability and the absorption, distribution, metabolism and excretion (ADME) of inhaled londamocitinib ...
Camille Riff, Peter Bold, Maria Heijer, Ryan A. Bragg, Danielle Steele, Tina Jellesmark Jensen, Davinder P. S. Dosanjh, Sabrina I. Hanswijk‐Bartelds, Esther van Duijn, Elwin R. Verheij, Somasekhara Menakuru, Rod Hughes, Helena Dahlbäck   +12 more
wiley   +1 more source

Technology-Based Interventions for Substance Use Treatment Among People Who Identify as African American or Black, Hispanic or Latino, and American Indian or Alaska Native: Scoping Review. [PDF]

J Med Internet Res
Moore SK, Boggis JS, Gauthier PR, Lambert-Harris CA, Hichborn EG, Bell KD, Saunders EC, Montgomery L, Murphy EI, Turner AM, Agosti N, McLeman BM, Marsch LA.   +12 more
europepmc   +1 more source

Phase 1, open‐label, randomized study of the elecoglipron pharmacokinetic profile in healthy participants under fed and fasted conditions

British Journal of Clinical Pharmacology, EarlyView.
Aims Elecoglipron (AZD5004/ECC5004) is an oral small‐molecule glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) in development for weight management in people living with obesity or overweight and type 2 diabetes. This study aimed to characterize the pharmacokinetics (PK) profiles of two formulations of elecoglipron under fed and fasted conditions ...
Jianfeng Xu, Amina Haggag, Laurie Butcher, Haihui Liu, Wen Chen, Xuefeng Sun, Aruni Jha, Hongtao Yu, Anis Khan, Victoria E. R. Parker, Christer Tannergren, Xiaoliang Pan, Jianfeng Xu, Jingye Zhou   +13 more
wiley   +1 more source

Chilean science teachers' conceptualisations of disability when teaching students with autism

British Educational Research Journal, EarlyView.
Abstract This study examines how Chilean secondary science teachers conceptualise disability when teaching students with autism in integrated classroom settings. Grounded in critical disability studies, the research employs a qualitative story‐completion method, using a fictional classroom scenario to prompt teachers to construct narratives that reveal
Alexis Gonzalez‐Donoso, Fabian Arroyo‐Rojas   +1 more
wiley   +1 more source

Industrial Symbiosis as a Neglected Opportunity in Industrial Decarbonisation Pathways: Qualitative Insights From the Australian Manufacturing Sector

Business Strategy and the Environment, EarlyView.
ABSTRACT Industrial symbiosis (IS) represents a key strategy for industrial decarbonisation (ID) by converting one industry's waste into valuable inputs for another, reducing emissions and resource extraction. Scientific studies have explored the concept, implementation approaches and theoretical foundations of IS.
Marzieh Dehghan Niri, A S M Monjurul Hasan, Andrea Trianni   +2 more
wiley   +1 more source

Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos. [PDF]

Alzheimers Dement
Xia R, Jian X, Rodrigue AL, Bressler J, Boerwinkle E, Cui B, Daviglus ML, DeCarli C, Gallo LC, Glahn DC, Knowles EEM, Moon JY, Mosley TH, Satizabal CL, Sofer T, Tarraf W, Testai F, Blangero J, Seshadri S, González HM, Fornage M.   +20 more
europepmc   +1 more source

Fair Business Models for Climate‐Smart Agriculture: A Design Science Research Approach

Business Strategy and the Environment, EarlyView.
ABSTRACT Organisations in agri‐food value chains face urgent demands to address climate change, environmental degradation and social inequities through climate‐smart agriculture (CSA). However, sustained CSA implementation remains constrained by business models (BMs) that fail to offer fair solutions to stakeholders. Existing business model innovation (
Christopher Jr. Galgo, Gohar Isakhanyan, Jos Bijman, Verena Otter, Katja Logatcheva, Michiel van Galen, Marilena Gemtou, Liselotte Puggaard, Magdalena Nertinger, Jon Bienzobas Adrián   +9 more
wiley   +1 more source