Results 1 to 10 of about 38,061 (191)

Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Carbonic anhydrases (CAs, EC 4.2.1.1) activators were shown to be involved in memory enhancement and learning in animal models of cognition. Here we investigated the CA activating effects of a large series of histamine based compounds, including ...
Gustavo Provensi, Alessio Nocentini, Maria Beatrice Passani, Patrizio Blandina, Claudiu T. Supuran   +4 more
doaj   +2 more sources

PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity [PDF]

Cells, 2014
Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors.
Xingjuan Chen, Christian Egly, Ashley M. Riley, Wennan Li, Paul Tewson, Thomas E. Hughes, Anne Marie Quinn, Alexander G. Obukhov   +7 more
doaj   +4 more sources

Anti-Allergic Cromones Inhibit Histamine and Eicosanoid Release from Activated Human and Murine Mast Cells by Releasing Annexin A1 [PDF]

, 2013
PMCID: PMC3601088This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Ahluwalia, A Mulla, AB Kay, Ajantha Sinniah, AM Lucas, Bernhard Ryffel, C Bandeira-Melo, C Dahl, CD John, CF Schwender, CF Schwender, CP Sung, CP Sung, DS Thomson, E Solito, E Solito, E Wells, EB Cook, Egle Solito, F D'Acquisto, FL Pearce, FN Gavins, FS Ng, G Folkerts, G Galatowicz, J Raud, JD Croxtall, JP Tarayre, JP Tarayre, JP Tarayre, JS Cox, JS Cox, JS Cox, JS Cox, K Kuriyama, L Jenkins, L Wang, M Corbel, M Perretti, M Shichijo, MK Church, NJ Goulding, PJ Barnes, R Sagi-Eisenberg, RH Grace, RJ Rintala, RM Viscardi, Rod J. Flower, RP Hayhoe, S Mattoli, S Murphy, S Pieretti, S Yazid, S Yazid, Samia Yazid, SH Lee, SH Peers, SI Wasserman, SilvaJR Lapa e, SK Bansal, SM Oliani, T Du, T Oka, T Radeau, TC Theoharides, TC Theoharides, TW Evans, Virginia Calder, WM Abraham, WM Abraham, Y Okayama, Y Yang, Y Zuo, YW Chung   +73 more
core   +13 more sources

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

Frontiers in Pharmacology, 2021
This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart.
Joachim Neumann, Uwe Kirchhefer, Stefan Dhein, Britt Hofmann, Ulrich Gergs   +4 more
doaj   +1 more source

Revisiting Preclinical Observations of Several Histamine H3 Receptor Antagonists/Inverse Agonists in Cognitive Impairment, Anxiety, Depression, and Sleep–Wake Cycle Disorder

Frontiers in Pharmacology, 2022
A relationship appears to exist between dysfunction of brain histamine (HA) and various neuropsychiatric brain disorders. The possible involvement of brain HA in neuropathology has gained attention recently, and its role in many (patho)physiological ...
Mera Alhusaini, Mera Alhusaini, Nermin Eissa, Nermin Eissa, Nermin Eissa, Ali K. Saad, Ali K. Saad, Rami Beiram, Rami Beiram, Bassem Sadek, Bassem Sadek   +10 more
doaj   +1 more source

The Bronchoprotective Effects of Dual Pharmacology, Muscarinic Receptor Antagonist and β₂ Adrenergic Receptor Agonist Navafenterol in Human Small Airways

Cells, 2023
Bronchodilators and anti-inflammatory agents are the mainstream treatments in chronic obstructive and pulmonary disease (COPD) and asthma.
Joseph Antony Jude, Ian Dainty, Nikhil Karmacharya, William Jester, Reynold Panettieri   +4 more
doaj   +1 more source

Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor

Nature Communications, 2023
Histamine is a biogenic amine that participates in allergic and inflammatory processes by stimulating histamine receptors. The histamine H4 receptor (H4R) is a potential therapeutic target for chronic inflammatory diseases such as asthma and atopic ...
Dohyun Im, Jun-ichi Kishikawa, Yuki Shiimura, Hiromi Hisano, Akane Ito, Yoko Fujita-Fujiharu, Yukihiko Sugita, Takeshi Noda, Takayuki Kato, Hidetsugu Asada, So Iwata   +10 more
doaj   +1 more source

Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats

Journal of Neuroinflammation, 2020
Background Microglia, the principal sentinel immune cells of the central nervous system (CNS), play an extensively vital role in neuroinflammation and perioperative neurocognitive disorders (PND).
Yi-Nan Chen, Huan-Huan Sha, Yi-Wei Wang, Qin Zhou, Piplu Bhuiyan, Na-Na Li, Yan-Ning Qian, Hong-Quan Dong   +7 more
doaj   +1 more source

Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells. [PDF]

PLoS ONE, 2015
Asthma is characterized by airway inflammation and airflow obstruction from human airway smooth muscle (HASM) constriction due to increased local bronchoconstrictive substances.
Blanca Camoretti-Mercado, Susan H Pauer, Hwan Mee Yong, Dan'elle C Smith, Deepak A Deshpande, Steven S An, Stephen B Liggett   +6 more
doaj   +1 more source

Inverse Agonistic Activity of Antihistamines and Suppression of Histamine H1 Receptor Gene Expression

Journal of Pharmacological Sciences, 2012
Histamine H1 receptor (H1R) expression influences the severity of allergy symptoms. We examined the effect of inverse agonists on H1R gene expression. Two inverse agonists (carebastine and mepyramine), but not the neutral antagonist oxatomide, decreased ...
Hiroyuki Mizuguchi, Shohei Ono, Masashi Hattori, Hiroyuki Fukui   +3 more
doaj   +1 more source