Results 141 to 150 of about 467,605 (318)

Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pitolisant, an FDA‐approved H3R antagonist, counteracts the rewarding and sedative effects of ethanol, reduces alcohol intake, and alleviates the negative affect during withdrawal. This might occur via the antagonism of presynaptic autoreceptors and heteroreceptors H3Rs in the lateral habenula, thereby activating the H2R/p‐CREB/BDNF signaling and ...
Yan Zhao   +13 more
wiley   +1 more source

4-(ω-(Alkyloxy)alkyl)-1H-imidazole Derivatives as Histamine H3Receptor Antagonists/Agonists

open access: green, 2004
Galina Meier   +9 more
openalex   +1 more source

Glucomannan from Dendrobium officinale Alleviates Colitis via Modulating Gut Microbiota and Upregulating Deoxycholic Acid Production

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Dietary fiber is a bioactive substance that can modulate gut microbiota and exert a relieving effect on inflammatory bowel disease (IBD). Dendrobium officinale polysaccharide (DOP) is a type of bioactive dietary fiber that has been proven to have various biological activities on intestinal function.
Jie Xu   +7 more
wiley   +1 more source

Rosmarinic Acid as A Flavonoids Ameliorated Cytokines and Oxidative Stress Biomarkers in the Lung Lavage Fluid of Rats

open access: yesFood Science &Nutrition, Volume 14, Issue 1, January 2026.
Levels of IL‐4, IFN‐γ and NO2 in broncho alveolar lavage fluid (BALF). ABSTRACT Allergic asthma is a chronic respiratory condition characterized by pronounced inflammation, oxidative stress, and reversible airway obstruction. The objective of this study was to assess the effects of rosmarinic acid (RosA) on the mitigation of inflammation and oxidative ...
Vahideh Abbasnia   +2 more
wiley   +1 more source

Evaluation of Total Serum IgE Level and Associated Factors in Asthmatic Patients at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross‐Sectional Study

open access: yesHealth Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Asthma is a chronic respiratory disorder with both genetic and environmental underlying risk factors. Allergic asthma, the most prevalent kind, is mostly ascribed to aberrant T helper type 2 (Th2) inflammation and is brought on by allergens.
Ayenew Assefa   +2 more
wiley   +1 more source

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