Results 151 to 160 of about 38,061 (191)

Histamine H3 Receptor Agonists

Mini-Reviews in Medicinal Chemistry, 2004
The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.
I J P, De Esch, K J, Belzar
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Cardiac Effects of Novel Histamine H2 Receptor Agonists

The Journal of Pharmacology and Experimental Therapeutics, 2021
In an integrative approach, we studied cardiac effects of recently published novel H2 receptor agonists in the heart of mice that overexpress the human H2 receptor (H2-TG mice) and littermate wild type (WT) control mice and in isolated electrically driven muscle preparations from patients undergoing cardiac surgery.
Ulrich, Gergs, Maren L, Büxel, Merlin, Bresinsky, Uwe, Kirchhefer, Charlotte, Fehse, Carina, Höring, Britt, Hofmann, Margaréta, Marušáková, Aneta, Čináková, Rebecca, Schwarz, Steffen, Pockes, Joachim, Neumann   +11 more
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Histamine H4 receptor agonists

Bioorganic & Medicinal Chemistry Letters, 2010
Since its discovery 10 years ago the histamine H(4) receptor (H(4)R) has attracted attention as a potential drug target, for instance, for the treatment of inflammatory and allergic diseases. Potent and selective ligands including agonists are required as pharmacological tools to study the role of the H(4)R in vitro and in vivo.
Patrick, Igel, Stefan, Dove, Armin, Buschauer   +2 more
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New selective histamine H1 agonists

Pharmaceutisch Weekblad, 1990
In this article the synthesis and histaminergic H1 activity of a series of substituted 2-phenylhistamines are described. It appeared that substitution of the phenyl ring of these compounds influences the H1 activity substantially. In general, substitution in para position causes a decrease in H1 activity.
J G, Koper, A, Van der Vliet, H, Van der Goot, H, Timmerman   +3 more
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Histamine Agonists and Antagonists

Acta Oto-Laryngologica, 1991
The role of histamine in brain function is discussed. A brief review is presented on the three types of histamine receptors with regard to their biochemistry and functions. The agonists and antagonists of these three classes of histamine receptors are discussed, together with the role such compounds play in clinical therapy and pharmacology.
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INHIBITION OF ACETYLCHOLINESTERASE BY HISTAMINE AGONISTS AND ANTAGONISTS

Clinical and Experimental Pharmacology and Physiology, 1985
SUMMARY1. The histamine H1 and/or H2‐receptor agonists showed weak acetylcholinesterase inhibitory activity. Their dissociation constants (Kis and/or Kii) were 2‐methyl histamine (Kis= 1751 μmol/1, s.e. = 163) < 4‐methyl histamine (Kis= 3551 μmol/1, s.e. = 414) < dimaprit (Kis= 2931 μmol/1, s.e. = 605; Kii= 3668 μmol/1, s.e. = 901) < histamine
Lee, H.S., Cheah, L.S., Gwee, M.C.E.
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Developments in histamine H1-receptor agonists

1995
The story of histamine started in the early 1900’s with the fundamental investigations of Dale et al. [l–3], which recognized the remarkable physiological behavior of this biogenic amine. Scientific progress over the past decades has proved that histamine interacts with specific histamine receptors as a neurotransmitter and nearly all mammalian tissues
V, Zingel, C, Leschke, W, Schunack
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