Results 151 to 160 of about 467,605 (318)

Role of Macrophages in Cardiac Remodeling: Cues From Zebrafish Heart

Immunity, Inflammation and Disease, Volume 14, Issue 1, January 2026.
The figure illustrates the role of macrophage polarization in cardiac damage and repair, highlighting monocyte to M0, M1, and M2 macrophage differentiation. M1 macrophages, in response to pro‐inflammatory cytokines (e.g., IFNγ, TNF‐α, IL‐6), are involved in fibrosis and scarring in the heart.
Himanshu Gaur, Maram Hasan, Huseyin C. Yalcin   +2 more
wiley   +1 more source

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry

ChemistryOpen, Volume 15, Issue 1, January 2026.
Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten, Raushan Koizhaiganova, Dilnaz Bissenbay, Bagila Tursynova, Zhanar Zhaxibayeva, Valentina Yu   +5 more
wiley   +1 more source

Stimulation of phospholipase C in cultured microvascular endothelial cells from human frontal lobe by histamine, endothelin and purinoceptor agonists [PDF]

, 1994
John R. Purkiss, David W. West, Leslie C. Wilkes, Caroline Scott, Peter Yarrow, Graeme Wilkinson, Michael R. Boarder   +6 more
openalex   +1 more source

Peculiarities of spirometric indices in schoolchildren with bronchial asthma, depending on their atopic status [PDF]

, 2016
In article on based analysis of spirometric indicators was researched the peculiarities of nonspecific bronchial hyperreactivity depending on the atopic status of school-age children.
Haras, M.N.
core  

The Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist Chlorpheniramine to Pregnant Rats Impairs the Development of Nigro-Striatal Dopaminergic Neurons

, 2019
Berenice Márquez‐Valadez, Guillermo Aquino-Miranda, Mijail-Oliver Quintero-Romero, Helena Papacostas-Quintanilla, Antonio Bueno-Nava, Carolina López‐Rubalcava, Néstor Fabián Díaz, José‐Antonio Arias‐Montaño, Anayansí Molina‐Hernández   +8 more
openalex   +1 more source

Ciproxifan, a Histamine H₃-Receptor Antagonist/Inverse Agonist, Potentiates Neurochemical and Behavioral Effects of Haloperidol in the Rat [PDF]

, 2002
Catherine Pillot, Jordí Ortiz, Anne Héron, Sophie Ridray, Jean‐Charles Schwartz, Jean‐Michel Arrang   +5 more
openalex   +1 more source

Critical evaluation of real‐world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract INTRODUCTION Repurposing Food and Drug Administration (FDA)‐approved drugs could accelerate treatment development for Alzheimer's disease (AD). METHODS Using the MarketScan claims database (2011 to 2020), we applied a trial emulation approach in two base cohorts: (1) individuals with mild cognitive impairment (MCI cohort) and (2) individuals ...
Reina Tonegawa‐Kuji, Ehud Karavani, Michael Danziger, Pengyue Zhang, Yuan Hou, Yadi Zhou, Marina Bykova, Andrew A. Pieper, Michal Rosen‐Zvi, Jeffrey Cummings, Feixiong Cheng   +10 more
wiley   +1 more source

Effects of opioids on ventilation and hemodynamics [PDF]

, 2007
Opioids are most commonly used for treatment of severe pain. However, the fear of respiratory depression has restricted the use of opioids. Depending on the monitoring system used, different modes of opioid respiratory effects have been noted in previous
Mildh, Leena
core  

Stimulus-response evaluation of the antipruritic effect of homotopic, monophasic cold and TRP-agonist counter-stimulation on histamine-induced itch in healthy volunteers

, 2015
Hjalte Holm Andersen, Amalie Randers, A. Simoni, Anne Jerwiarz, Camilla Melholt, Jacob B. Pedersen, Sigurd D. Hilborg, Jesper Elberling, Lars Arendt‐Nielsen   +8 more
openalex   +2 more sources

Natural History of Airway Hyperresponsiveness and Its Association With Asthma Traits

Allergy, Volume 81, Issue 1, Page 121-129, January 2026.
AHR improves in most children over adolescence when its relationship with asthma changes. AHR is better at ruling out asthma in children, while it is superior at ruling in asthma in young adults. Age should be considered when interpreting AHR, and different cutoffs might be required for children and adults.
Sophie Carra, Hongmei Zhang, Ramesh J. Kurukulaaratchy, Syed Hasan Arshad   +3 more
wiley   +1 more source