Results 11 to 20 of about 467,605 (318)

Cardiovascular effects of H3 histamine receptor inverse agonist/ H4 histamine receptor agonist, clobenpropit, in hemorrhage-shocked rats

PLOS ONE, 2018
Hemorrhagic shock has a potential to be life-threatening when it is not treated. The main causes of hemorrhagic shock involve: (1) forces causing injury; and (2) diseases that can cause hemorrhage., Therefore, due to the causes of hemorrhagic shock and the life-threatening potential, the search for new methods of shock treatment is extremely valuable ...
Bartosz Wanot, Karolina Jasikowska, Ewa Niewiadomska, Agnieszka Biskupek-Wanot   +3 more
openaire   +6 more sources

Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists. [PDF]

Journal of Experimental Medicine, 1990
Human interleukin 5 (IL-5), known as a selective colony-stimulating factor of the eosinophil lineage and activator of mature eosinophils, also profoundly influences the mediator release profile of human basophils.
Stephan C. Bischoff, Thomas Brunner, A.L. de Weck, Clemens A. Dahinden   +3 more
openalex   +2 more sources

HISTAMINE H3 RECEPTOR INVERSE AGONISTS ON COGNITIVE AND MOTOR PROCESSES: RELEVANCE TO ALZHEIMER’S DISEASE, ADHD, SCHIZOPHRENIA AND DRUG ABUSE

Frontiers in Systems Neuroscience, 2012
Histamine H3 receptor antagonists/ inverse agonists possess potential to treat diverse disease states of the central nervous system (CNS). Cognitive dysfunction and motor impairments are the hallmark of multifarious neurodegenerative and/or psychiatric ...
Divya eVohora, Malay eBhowmik
doaj   +2 more sources

Histamine H1‐receptor‐mediated modulation of NMDA receptors signaling responses [PDF]

Pharmacology Research & Perspectives
This study attempted to clarify the role of histamine H1 receptors in epilepsy by exploring the effects of agonists and inverse agonists on the rundown of the current induced by iterative applications of NMDA or GABA in primary neuronal culture ...
J.‐M. Arrang, V. Armand
doaj   +2 more sources

Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice [PDF]

Molecular Brain
The histaminergic system plays a key role in modulating learning and memory, wakefulness, and energy balance. Histamine H3 receptors constitutively inhibit the synthesis and release of histamine and other neurotransmitters. Therefore, H3 receptor inverse
Sentaro Kaita, Yoshikazu Morishita, Kenta Kobayashi, Hiroshi Nomura   +3 more
doaj   +2 more sources

New developments around histamine H₃receptor antagonists/inverse agonists: a patent review (2010 – present)

Expert Opinion on Therapeutic Patents, 2013
Dorota Łażewska, Katarzyna Kieć‐Kononowicz   +1 more
openalex   +3 more sources

Anti-Allergic Cromones Inhibit Histamine and Eicosanoid Release from Activated Human and Murine Mast Cells by Releasing Annexin A1 [PDF]

, 2013
PMCID: PMC3601088This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Ahluwalia, A Mulla, AB Kay, Ajantha Sinniah, AM Lucas, Bernhard Ryffel, C Bandeira-Melo, C Dahl, CD John, CF Schwender, CF Schwender, CP Sung, CP Sung, DS Thomson, E Solito, E Solito, E Wells, EB Cook, Egle Solito, F D'Acquisto, FL Pearce, FN Gavins, FS Ng, G Folkerts, G Galatowicz, J Raud, JD Croxtall, JP Tarayre, JP Tarayre, JP Tarayre, JS Cox, JS Cox, JS Cox, JS Cox, K Kuriyama, L Jenkins, L Wang, M Corbel, M Perretti, M Shichijo, MK Church, NJ Goulding, PJ Barnes, R Sagi-Eisenberg, RH Grace, RJ Rintala, RM Viscardi, Rod J. Flower, RP Hayhoe, S Mattoli, S Murphy, S Pieretti, S Yazid, S Yazid, Samia Yazid, SH Lee, SH Peers, SI Wasserman, SilvaJR Lapa e, SK Bansal, SM Oliani, T Du, T Oka, T Radeau, TC Theoharides, TC Theoharides, TW Evans, Virginia Calder, WM Abraham, WM Abraham, Y Okayama, Y Yang, Y Zuo, YW Chung   +73 more
core   +13 more sources

The Bronchoprotective Effects of Dual Pharmacology, Muscarinic Receptor Antagonist and β₂ Adrenergic Receptor Agonist Navafenterol in Human Small Airways

Cells, 2023
Bronchodilators and anti-inflammatory agents are the mainstream treatments in chronic obstructive and pulmonary disease (COPD) and asthma.
Joseph Antony Jude, Ian Dainty, Nikhil Karmacharya, William Jester, Reynold Panettieri   +4 more
doaj   +1 more source

Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells. [PDF]

PLoS ONE, 2015
Asthma is characterized by airway inflammation and airflow obstruction from human airway smooth muscle (HASM) constriction due to increased local bronchoconstrictive substances.
Blanca Camoretti-Mercado, Susan H Pauer, Hwan Mee Yong, Dan'elle C Smith, Deepak A Deshpande, Steven S An, Stephen B Liggett   +6 more
doaj   +1 more source

Inverse Agonistic Activity of Antihistamines and Suppression of Histamine H1 Receptor Gene Expression

Journal of Pharmacological Sciences, 2012
Histamine H1 receptor (H1R) expression influences the severity of allergy symptoms. We examined the effect of inverse agonists on H1R gene expression. Two inverse agonists (carebastine and mepyramine), but not the neutral antagonist oxatomide, decreased ...
Hiroyuki Mizuguchi, Shohei Ono, Masashi Hattori, Hiroyuki Fukui   +3 more
doaj   +1 more source