Results 31 to 40 of about 467,605 (318)

Increased Sensitivity of Mice Lacking Extrasynaptic δ-Containing GABAA Receptors to Histamine Receptor 3 Antagonists

Frontiers in Pharmacology, 2020
Histamine/gamma-aminobutyric acid (GABA) neurons of posterior hypothalamus send wide projections to many brain areas and participate in stabilizing the wake state.
Shamsiiat Abdurakhmanova, Milo Grotell, Jenna Kauhanen, Anni-Maija Linden, Esa R. Korpi, Pertti Panula   +5 more
doaj   +1 more source

The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands. [PDF]

PLoS ONE, 2016
In this article we report a combined experimental and computational study concerning the effects of deuteration on the binding of histamine and two other histaminergic agonists to 3H-tiotidine-labeled histamine H2 receptor in neonatal rat astrocytes ...
Mojca Kržan, Robert Vianello, Aleksandra Maršavelski, Matej Repič, Maja Zakšek, Kristina Kotnik, Estera Fijan, Janez Mavri   +7 more
doaj   +1 more source

Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge [PDF]

, 2012
Background: Both standard and low-dose allergen provocations are an established tool in asthma research to improve our understanding of the pathophysiological mechanism of allergic asthma.
Rose, Markus A., Schubert, Ralf, Schulze, Johannes, Voss, Sandra, Zielen, Stefan, Zissler, Ulrich   +5 more
core   +2 more sources

Antihistaminergics and inverse agonism. Potential therapeutic applications [PDF]

, 2013
The accurate characterization of the molecular mechanisms involved in the action of receptor ligands is important for their appropriate therapeutic use and safety.
Davio, Carlos Alberto, Fernández, Natalia Brenda, Fitzsimons, Carlos, Monczor, Federico, Shayo, Carina Claudia   +4 more
core   +9 more sources

The Regulation of ICAM-1 and LFA-1 Interaction by Autacoids and Statins: a Novel Strategy for Controlling Inflammation and Immune Responses

Journal of Pharmacological Sciences, 2003
Histamine, prostaglandin E2, and catecholamines have been demonstrated to regulate the innate and acquired immune responses. In this review, we describe one of the mechanisms common to the action of these agonists; the regulation of the expression of ...
Masahiro Nishibori, Hideo K. Takahashi, Shuji Mori   +2 more
doaj   +1 more source

Ageing influences detrusor contractions to prostaglandin, angiotensin, histamine and 5-HT (serotonin), independent to the Rho kinase and extracellular calcium pathways

Scientific Reports, 2023
Ageing is associated with deteriorating urinary bladder function and an increasing prevalence of disorders such as underactive bladder. There are suggestions that G protein-coupled receptor (GPCR) second messenger pathways are altered during ageing ...
Charlotte Phelps, Russ Chess-Williams, Christian Moro   +2 more
doaj   +1 more source

Participation of Histamine H3 Receptors in Experimental Allergic Rhinitis of Mice

Journal of Pharmacological Sciences, 2008
The present study was performed to study the participation of histamine H3 receptors in nasal symptoms using Sch 50971, a potent and selective agonist of the H3 receptor.
Emiko Yokota, Shoji Kuyama, Yukio Sugimoto, Masami Ogawa, Chiaki Kamei   +4 more
doaj   +1 more source

The impact of pitolisant, an H3 receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels

Scientific Reports, 2022
Histamine is a neurotransmitter that modulates neuronal activity and regulates various brain functions. Histamine H3 receptor (H3R) antagonists/inverse agonists enhance its release in most brain regions, including the cerebral cortex, which improves ...
Kyosuke Hirano, Yoshikazu Morishita, Masabumi Minami, Hiroshi Nomura   +3 more
doaj   +1 more source

Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]

, 2004
Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C., Laakmann, G., Schule, C.   +2 more
core   +1 more source

Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine. [PDF]

, 2019
Histamine (HA) is an important food contaminant generated during food fermentation or spoilage. However, an immunoassay for direct (derivatization free) determination of HA has rarely been reported due to its small size to induce the desired antibodies ...
Dong, Jie-Xian, Hammock, Bruce, Jia, Bao-Zhu, Lei, Hong-Tao, Luo, Lin, Shen, Yu-Dong, Wang, Hong, Wei, Xiao-Qun, Xu, Zhen-Lin, Yang, Jin-Yi   +9 more
core   +1 more source