Results 81 to 90 of about 38,061 (191)

The mechanisms of calcium homeostasis and signalling in the lens [PDF]

, 2008
Excessive Ca2+ can be detrimental to cells and raised levels of Ca2+ in human lenses with cortical cataract have been found to play a major role in the opacification process.
Rhodes, JD, Sanderson, J
core   +1 more source

Cryo-EM Structures and AlphaFold3 Models of Histamine Receptors Reveal Diverse Ligand Binding and G Protein Bias

Pharmaceuticals
Background: The four subtypes of G protein-coupled receptors (GPCRs) regulated by histamine play critical roles in various physiological and pathological processes, such as allergy, gastric acid secretion, cognitive and sleep disorders, and inflammation.
Anqi Chen, Chenxi Su, Zisu Zhang, Haitao Zhang   +3 more
doaj   +1 more source

Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation.

PLoS Pathogens, 2019
Kaposi's sarcoma-associated herpesvirus (KSHV) causes several human cancers, such as Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). Current treatment options for KSHV infection and virus associated diseases are sometimes ineffective ...
Jungang Chen, Lu Dai, Alana Goldstein, Haiwei Zhang, Wei Tang, J Craig Forrest, Steven R Post, Xulin Chen, Zhiqiang Qin   +8 more
doaj   +1 more source

Chemogenetic activation of histamine neurons promotes retrieval of apparently lost memories

Molecular Brain
Memory retrieval can become difficult over time, but it is important to note that memories that appear to be forgotten might still be stored in the brain, as shown by their occasional spontaneous retrieval.
Yuto Yokoi, Ayame Kubo, Kyoka Nishimura, Yuki Takamura, Yoshikazu Morishita, Masabumi Minami, Hiroshi Nomura   +6 more
doaj   +1 more source

Spasmolytic effect of traditional herbal formulation on guinea pig ileum

Journal of Ayurveda and Integrative Medicine, 2015
Background: The herbal formulation consisting of Andrographis paniculata Nees., Cassia fistula L., Foeniculum vulgare Mill. and Cuminum cyminum L. is widely used by the local traditional practitioners in rural Northern Karnataka for spasmodic abdominal ...
Dushyant Kumar, Kuntal Ganguly, H V Hegde, P A Patil, S D Kholkute   +4 more
doaj   +1 more source

The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [PDF]

, 2018
Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Erowid, Earth, Erowid, Fire, Martínez Vivot, Rocío, Pallavicini, Carla, Sanz, Camila, Tagliazucchi, Enzo Rodolfo, Zamberlan, Federico   +6 more
core   +2 more sources

Targeting Microglia in Neuroinflammation: H3 Receptor Antagonists as a Novel Therapeutic Approach for Alzheimer’s Disease, Parkinson’s Disease, and Autism Spectrum Disorder

Pharmaceuticals
Histamine performs dual roles as an immune regulator and a neurotransmitter in the mammalian brain. The histaminergic system plays a vital role in the regulation of wakefulness, cognition, neuroinflammation, and neurogenesis that are substantially ...
Shilu Deepa Thomas, Sabna Abdalla, Nermin Eissa, Amal Akour, Niraj Kumar Jha, Shreesh Ojha, Bassem Sadek   +6 more
doaj   +1 more source

An ab initio study of histamine agonists.

Indian journal of biochemistry & biophysics, 1998
A systematic theoretical study on histamine agonists and their interaction with H1 and H2 receptor models has been carried out utilizing ab initio molecular orbital technique. The effect of substituents on histamine agonists' charge distribution and their agonistic activity has been studied in detail.
A, Yadav, V K, Yadav
openaire   +1 more source

The five primary prostaglandins stimulate contractions and phasic activity of the urinary bladder urothelium, lamina propria and detrusor [PDF]

, 2020
Chess-Williams, Russ, Moro, Christian, Stromberga, Zane   +2 more
core   +1 more source

Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice

Mediators of Inflammation, 1993
Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of ...
Nora Goren, Claudia Perez Leiros, Leonor Sterin-Borda, Enri S. Borda   +3 more
doaj   +1 more source