Results 81 to 90 of about 467,605 (318)

The Influence of Mast Cell Mediators on Migration of SW756 Cervical Carcinoma Cells

Journal of Pharmacological Sciences, 2008
The role of mast cell mediators on cervical cancer cell migration was assessed using an in vitro assay of scratch wound healing onto monolayers of HPV18-positive cervical carcinoma cells (SW756).
M. Isolde Rudolph, Yadira Boza, Roger Yefi, Sandra Luza, Edilia Andrews, Alicia Penissi, Pablo Garrido, I. Gina Rojas   +7 more
doaj   +1 more source

Pharmacogenomic and structural analysis of constitutive G-protein coupled receptor activity [PDF]

, 2007
Premi a l'excel·lència investigadora. Àmbit de les Ciències de la Salut. 2008G-protein coupled receptors (GPCRs) respond to a chemically diverse plethora of signal transduction molecules.
Aldo Jongejan, Alewijnse AE, Ariens EJ, Brown EM, Cesarman E, Chen F, Clark AJ, Clark AJ, Cobbs CS, Furchgott RF, Furchgott RF, Garcia-Borron JC, Henk Timmerman, Henry F. Vischer, Leonardo Pardo, Mannstadt M, Martine J. Smit, Murphy PM, Nauta WT, Rauser L, Reiter EO, Remko A. Bakker, Rob Leurs, Rossier O, Samama P, Scheer A, Stephenson RP, Tabs S, Weiner DM, Wieland K   +29 more
core   +3 more sources

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Antidiabetic Properties of the Histamine H3 Receptor Protean Agonist Proxyfan [PDF]

Endocrinology, 2011
Proxyfan is a histamine H3 receptor protean agonist that can produce a spectrum of pharmacological effects including agonist, inverse agonist, and antagonist. We have discovered that proxyfan (10 mg/kg orally) significantly improved glucose excursion after an ip glucose tolerance test in either lean or high-fat/cholesterol diet-induced obese mice.
Melanie B, Henry, Shuqin, Zheng, Chenxia, Duan, Bhuneshwari, Patel, Galya, Vassileva, Christopher, Sondey, Jean, Lachowicz, Joyce J, Hwa   +7 more
openaire   +2 more sources

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

The role of carcinine in signaling at the Drosophila photoreceptor synapse. [PDF]

PLoS Genetics, 2007
The Drosophila melanogaster photoreceptor cell has long served as a model system for researchers focusing on how animal sensory neurons receive information from their surroundings and translate this information into chemical and electrical messages ...
Brendan A Gavin, Susan E Arruda, Patrick J Dolph   +2 more
doaj   +1 more source

Histamine inhibits adrenocortical cell proliferation but does not affect steroidogenesis. [PDF]

, 2014
Histamine (HA) is a neurotransmitter synthesized in most mammalian tissues exclusively by histidine decarboxylase enzyme. Among the plethora of actions mediated by HA, the modulatory effects on steroidogenesis and proliferation in Leydig cells (LCs) have
Mondillo, Carolina, Monzón, Casandra Margarita, Pagotto, Romina María del Luján, Pereyra, Elba Nora, Pignataro, Omar Pedro   +4 more
core   +2 more sources

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Basophil activation through TLR2 and TLR4 signaling pathways

AIMS Allergy and Immunology, 2018
Basophils are effector cells that respond to protease allergens and parasites, thus contributing to allergic inflammation and Th2 differentiation. However, the molecular interactions through which pathogens promote activation as well as recruitment of ...
Manal Alkan, Fadel Sayes, Abdulraouf Ramadan, Francois Machavoine, Michel Dy, Elke Schneider, Nathalie Thieblemont   +6 more
doaj   +1 more source

Monoaminergic Neuropathology in Alzheimer's disease [PDF]

, 2016
Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira, Buée, Luc, Delalle, Ivana, Giovanni, Giuseppe Di, Harrington, Charles R., Hof, Patrick R., Jovanov-Milošević, Nataša, Leko, Mirjana Babić, Silva, Rohan de, Wischik, Claude M., Wray, Selina, Šimić, Goran   +11 more
core   +1 more source