Results 121 to 130 of about 10,782,665 (139)

Serum Protein Binding of Histamine H1-Antagonists. A Comparative Study on the Serum Protein Binding of a Sedating ([3H]Mepyramine) and a Non-Sedating H1-Antagonist ([3H]Loratadine)

European Journal of Pharmaceutical Sciences, 1996
Abstract Nowadays classical histamine H 1 -receptor antagonists (antihistamines) are relatively rarely used in therapy against allergic disorders, mainly because they are able to penetrate the central nervous system (CNS) and induce subsequently unwanted side effects (most importantly sedation).
J Wilting, H Timmerman
exaly   +3 more sources

The Clinical Pharmacology of Non-Sedating Antihistamines [PDF]

Pharmacology & Therapeutics, 2017
We previously reported on brain H1 receptor occupancy measurements of antihistamines in human brain using [11C]doxepin and positron emission tomography (PET).
Kazuhiko Yanai, Tadaho Nakamura, Takeo Yoshikawa   +2 more
exaly   +2 more sources

Blood distribution of levocetirizine, a new non‐sedating histamine H₁‐receptor antagonist, in humans

Fundamental & Clinical Pharmacology, 2002
AbstractThe aim of the present study was to determine (1) the extent of levocetirizine binding to human blood cells, plasma and individual plasma proteins; (2) the parameters for levocetirizine binding to individual plasma proteins both at their physiological concentrations and, for human serum albumin (HSA), at a lower saturating concentration; and (3)
Françoise, Bree, Laetitia, Thiault, Gwenaelle, Gautiers, Margherita Strolin, Benedetti, Eugène, Baltes, Jean-Pierre, Rihoux, Jean-Paul, Tillement   +6 more
openaire   +2 more sources

Comparison of Non-Sedating and Sedating Histamine H1-Receptor Antagonist Premedication for Preventing Subcutaneous Daratumumab-Associated Infusion-Related Reactions: A Multicenter Retrospective Observational Study

Keio Journal of Medicine
Sedating antihistamines (sAH) are widely used as premedication to prevent infusion-related reactions (IRRs). Subcutaneous daratumumab (DARA-SC) is administered in a shorter time than its intravenous form. Therefore, sedation caused by sAH after DARA-SC administration may also pose a concern.
Tatsuya Hayama, Akihiro Uchiike, Haruki Ishikawa   +2 more
exaly   +2 more sources

Dangers of Non-Sedating Antihistamines

Lancet, The, 1997
Alexander Cohen
exaly   +4 more sources

Brain Histamine H1 Receptor Occupancy Measured by PET After Oral Administration of Levocetirizine, a Non-Sedating Antihistamine

Expert Opinion on Drug Safety, 2015
Kiichi Ishiwata, Kazuhiko Yanai, Kenji Ishii   +2 more
exaly  

Antihistamine Activity, Central Nervous System and Cardiovascular Profiles of Histamine H1 Antagonists: Comparative Studies With Loratadine, Terfenadine and Sedating Antihistamines in Guinea-Pigs

Clinical and Experimental Allergy, 1995
William Kreutner, J A Hey, M del Prado
exaly  

Selective Inhibition of Peripheral Histamine Responses by Loratadine and Terfenadine

European Journal of Pharmacology, 1990
Richard W. Chapman, William Kreutner, Robert W Egan   +2 more
exaly  

Selective Displacement of [3H]Mepyramine From Peripheral vs. Central Nervous System Receptors by Loratadine, a Non-Sedating Antihistamine

European Journal of Pharmacology, 1986
Allen Barnett, A Barnett
exaly  

Comparative Study of Central and Peripheral Histamine-H1 Receptor Binding in Vitro and Ex Vivo of Non-Sedating Antihistamines and of Noberastine, a New Agent

Drug Development Research, 1991
Paul A J Janssen, Walter Gommeren, Paul F M Janssen   +2 more
exaly