Results 101 to 110 of about 12,080 (218)
Therapeutic potential of histamine H3 receptor agonists and antagonists
Trends in Pharmacological Sciences, 1998 The histamine H3 receptor was discovered 15 years ago, and many potent and selective H3 receptor agonists and antagonists have since been developed. Currently, much attention is being focused on the therapeutic potential of H3 receptor ligands. In this review, Rob Leurs, Patrizio Blandina, Clark Tedford and Henk Timmerman describe the available H3 ...
R. LEURS +3 more
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H3 antagonists and postoperative cognitive dysfunction
Journal of Anaesthesiology Clinical Pharmacology, 2019 Since histamine (HA) was first synthesized in 1907 and isolated as a bacterial contaminant of an extract of ergot in 1910, its role in health and disease and its molecular mechanism of action have been unraveled, leading to the formulation of an array of
Chandrasekhar Krishnamurti
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Gαi and GƔ30A act downstream of Tre1 in Drosophila courtship [PDF]
, 2019 The role of genes in morphological development is well understood for a variety of model organisms, but there remains a gap in our understanding of how genetics mediate behavior. Are there master genes that regulate behavior? Answering this question will
Mu, Emily
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Mice in ecstasy : advanced animal models in the study of MDMA [PDF]
, 2010 The party drug 3,4-methylenedioxymethamphetamine -better known as MDMA or ecstasy- has numerous effects on the human body, characterized by a rush of energy, euphoria and empathy.
Stove, Christophe +3 more
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The Histamine H3 Receptor and Eating Behavior
The Journal of Pharmacology and Experimental Therapeutics, 2011 Interest in the histaminergic system as a potential target for the treatment of feeding disorders is driven by the unsatisfactory history of the pharmacotherapy of obesity. Eating behavior is regulated by a complex interplay of central neurotransmitter systems, peripheral endocrine stimuli, the circadian rhythm, and environmental cues, all factors that
Passani, Maria Beatrice +2 more
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Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats. [PDF]
, 2018 RATIONALE: Accumulating evidence shows that cocaine, and also heroin, influence several tyrosine kinases, expressed in neurons and in non-neuronal populations such as microglia, astrocytes and mast-cells.
Belin, David +5 more
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Drug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands
Drug Design, Development and Therapy, 2014 Bassem Sadek,1 Annemarie Schreeb,2 Johannes Stephan Schwed,2,3 Lilia Weizel,2 Holger Stark3 1Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; 2Biocenter ...
Sadek B +4 more
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Frontiers in Psychiatry, 2012 Atypical antipsychotics such as clozapine and olanzapine have been shown to enhance histamine turnover and this effect has been hypothesized to contribute to their improved therapeutic profile compared to typical antipsychotics.
Kjell A Svensson
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Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues [PDF]
, 2020 Chess-Williams, Russ +2 more
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