H3 antagonists and postoperative cognitive dysfunction
Journal of Anaesthesiology Clinical Pharmacology, 2019 Since histamine (HA) was first synthesized in 1907 and isolated as a bacterial contaminant of an extract of ergot in 1910, its role in health and disease and its molecular mechanism of action have been unraveled, leading to the formulation of an array of
Chandrasekhar Krishnamurti
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0759 Phase 2 Proof Of Concept Study Of SUVN-G3031, A Histamine H3 Receptor Inverse Agonist For The Potential Treatment Of Narcolepsy [PDF]
, 2020 Ramakrishna Nirogi +6 more
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Histamine inhibits adrenocortical cell proliferation but does not affect steroidogenesis. [PDF]
, 2014 Histamine (HA) is a neurotransmitter synthesized in most mammalian tissues exclusively by histidine decarboxylase enzyme. Among the plethora of actions mediated by HA, the modulatory effects on steroidogenesis and proliferation in Leydig cells (LCs) have
Mondillo, Carolina +4 more
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The Histamine H3 Receptor and Eating Behavior
The Journal of Pharmacology and Experimental Therapeutics, 2011 Interest in the histaminergic system as a potential target for the treatment of feeding disorders is driven by the unsatisfactory history of the pharmacotherapy of obesity. Eating behavior is regulated by a complex interplay of central neurotransmitter systems, peripheral endocrine stimuli, the circadian rhythm, and environmental cues, all factors that
Passani, Maria Beatrice +2 more
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Novel chalcone-based fluorescent human histamine H3 receptor ligands as pharmacological tools
Frontiers in Systems Neuroscience, 2012 Novel fluorescent chalcone-based ligands at human histamine H3 receptors (hH3R) have been designed, synthesized and characterized. Compounds described are non-imidazole analogues of ciproxifan with a tetralone motif. Tetralones as chemical precursors and
Holger eStark
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Drug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands
Drug Design, Development and Therapy, 2014 Bassem Sadek,1 Annemarie Schreeb,2 Johannes Stephan Schwed,2,3 Lilia Weizel,2 Holger Stark3 1Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; 2Biocenter ...
Sadek B +4 more
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Radioligand binding and reporter gene assays for histamine H3 and H4 receptor species orthologs [PDF]
, 2013 Uwe Nordemann
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The histamine H3 receptor modulates dopamine D2 receptor-dependent signaling pathways and mouse behaviors. [PDF]
J Biol Chem, 2023 Xu J, Pittenger C.
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Gαi and GƔ30A act downstream of Tre1 in Drosophila courtship [PDF]
, 2019 The role of genes in morphological development is well understood for a variety of model organisms, but there remains a gap in our understanding of how genetics mediate behavior. Are there master genes that regulate behavior? Answering this question will
Mu, Emily
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