Results 121 to 130 of about 13,967 (254)

Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists

Drug Design, Development and Therapy, 2016
Bassem Sadek,1 Ali Saad,1 Johannes Stephan Schwed,2,3 Lilia Weizel,2 Miriam Walter,2 Holger Stark2,3 1Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates ...
Sadek B, Saad A, Schwed JS, Weizel L, Walter M, Stark H   +5 more
doaj  

Discovery of a Tritiated Radioligand with High Affinity and Selectivity for the Histamine H₃ Receptor. [PDF]

ACS Med Chem Lett, 2023
Mönnich D, Nagl M, Forster L, Rosier N, Igel P, Pockes S.   +5 more
europepmc   +1 more source

Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues [PDF]

, 2020
Chess-Williams, Russ, Moro, Christian, Stromberga, Zane   +2 more
core   +1 more source

Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control.
Jian Xin, Min Hu, Qian Liu, Tian Tai Zhang, Dong Mei Wang, Song Wu   +5 more
doaj   +1 more source

Effect of moderate prenatal ethanol exposure on the differential expression of two histamine H3 receptor isoforms in different brain regions of adult rat offspring. [PDF]

Front Neurosci, 2023
Davies S, Lujan KS, Rappaport EJ, Valenzuela CF, Savage DD.   +4 more
europepmc   +1 more source

Histamine H3 Receptor Antagonists Potentiate Methamphetamine Self-Administration and Methamphetamine-Induced Accumbal Dopamine Release [PDF]

, 2004
Patrik Munzar, Gianluigi Tanda, Zuzana Justinová, Steven R. Goldberg   +3 more
openalex   +1 more source

Structure-activity studies with histamine H3-receptor ligands.

Journal de pharmacie de Belgique, 1995
Analogues of thioperamide have been synthesised and tested in vitro on rat cerebral cortex to explore structure-activity relationships with the intention of designing compounds which do not possess the thiourea group of thioperamide and which may have improved brain penetration.
Ganellin, C. R., Fkyerat, A., Hosseini, S. K., Khalaf, Y. S., Piripitsi, A., Tertiuk, W., Arrang, J. M., Garbarg, M., Ligneau, X., Schwartz, J. C.   +9 more
openaire   +2 more sources

The Potent and Selective Histamine H3 Receptor Antagonist E169 Counteracts Cognitive Deficits and Mitigates Disturbances in the PI3K/AKT/GSK-3β Signaling Pathway in MK801-Induced Amnesia in Mice. [PDF]

Int J Mol Sci, 2023
Abdalla S, Eissa N, Jayaprakash P, Beiram R, Kuder KJ, Łażewska D, Kieć-Kononowicz K, Sadek B.   +7 more
europepmc   +1 more source

Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer’s disease

, 2020
Dorota Łażewska, Marek Bajda, Maria Kaleta, Paula Zaręba, Agata Doroż-Płonka, Agata Siwek, Alaa Alachkar, Szczepan Mogilski, Ali Saad, Kamil Kuder, Agnieszka Olejarz‐Maciej, Justyna Godyń, Dorota Stary, Sylwia Sudoł, Małgorzata Więcek, Gniewomir Latacz, Maria Walczak, Jadwiga Handzlik, Bassem Sadek, Barbara Malawska, Katarzyna Kieć‐Kononowicz   +20 more
openalex   +2 more sources

A Novel Potent and Selective Histamine H3 Receptor Antagonist Enerisant: In Vitro Profiles, In Vivo Receptor Occupancy, and Wake-Promoting and Procognitive Effects in Rodents [PDF]

, 2020
Noriko Hino, Toshiyuki Marumo, Makiko Kotani, Toshiharu Shimazaki, Ayaka Kaku-Fukumoto, Hirohiko Hikichi, Jun-ichi Karasawa, Yasumitsu Tomishima, Hiroko Komiyama, Emi Tatsuda, Dai Nozawa, Toshio Nakamura, Shigeyuki Chaki   +12 more
openalex   +1 more source