Results 201 to 210 of about 13,967 (254)

Decoding ligand recognition and constitutive activation of histamine H3 and H4 receptors

Sanshan Jin, Heng Zhang, Jiahui Yan, Canrong Wu, Xiaoqing Cai, Kaichun Wu, Ming-Wei Wang, H. Eric Xu, Dehua Yang, Yi Jiang   +9 more
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Histamine H3 receptor blockade alleviates neuropathic pain through the regulation of glial cells activation

Maciej Degutis, Dorota Łażewska, Justyna Barut, Magdalena Białoń, Gniewomir Latacz, Katarzyna Szczepańska, Wojciech Pietruś, Tobias Werner, Tadeusz Karcz, Holger Stark, Grzegorz Kreiner, Katarzyna Kieć‐Kononowicz, Katarzyna Starowicz, Katarzyna Popiołek-Barczyk   +13 more
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Non imidazole H3-receptor histamine antagonists

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Signal transduction of the histamine H3 receptor

, 2008
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Histamine H3 Receptor Agonists

Mini-Reviews in Medicinal Chemistry, 2004
The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.
I J P, De Esch, K J, Belzar
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Molecular aspects of the histamine H3 receptor

Biochemical Pharmacology, 2007
The cloning of the histamine H(3) receptor (H(3)R) cDNA in 1999 by Lovenberg et al. [10] allowed detailed studies of its molecular aspects and indicated that the H(3)R can activate several signal transduction pathways including G(i/o)-dependent inhibition of adenylyl cyclase, activation of phospholipase A(2), Akt and the mitogen activated kinase as ...
Gerold, Bongers, Remko A, Bakker, Rob, Leurs   +2 more
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H3 Receptor Miniseries: Histamine and H3 receptor in alcohol-related behaviors.

The Journal of Pharmacology and Experimental Therapeutics, 2020
Data from rat models for alcohol preference and histidine decarboxylase knockout (HDC KO) mice suggest that brain histamine regulates alcohol-related behaviors. Histamine levels are higher in alcohol-preferring than in alcohol-nonpreferring rat brains, and expression of histamine H(3) receptor (H(3)R) is different in key areas for addictive behavior. H(
Panula Pertti, Nuutinen Saara, Panula Pertti, Nuutinen Saara   +3 more
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Constitutive activity of the histamine H3 receptor

Trends in Pharmacological Sciences, 2007
Constitutive activity has been mainly recorded for numerous overexpressed and/or mutated receptors. The histamine H(3) receptor (H(3)R) is a target of choice to study the physiological relevance of this process. In rodent brain, postsynaptic H(3)Rs show high constitutive activity, and presynaptic H(3) autoreceptors that show constitutive activity have ...
Arrang, J.M., Morisset, S., Gbahou, Tedohe Florence   +2 more
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Fluorinated non-imidazole histamine H3 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2009
Fluorine substituents have become a widespread and important component in drug design and development. Here, the synthesis of fluorine containing compounds and some corresponding precursor molecules are presented for potential isotope labelling as well as their data obtained with in vitro and in vivo screenings. The compounds vary in the basic centres (
K, Isensee, M, Amon, A, Garlapati, A, Galaparti, X, Ligneau, J-C, Camelin, M, Capet, J-C, Schwartz, H, Stark   +8 more
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Histamine H3-receptor isoforms

Inflammation Research, 2004
Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor.
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