The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
The histamine H3 receptor: from gene cloning to H3 receptor drugs [PDF]
Nature Reviews Drug Discovery, 2005 Since the cloning of the histamine H(3) receptor cDNA in 1999 by Lovenberg and co-workers, this histamine receptor has gained the interest of many pharmaceutical companies as a potential drug target for the treatment of various important disorders, including obesity, attention-deficit hyperactivity disorder, Alzheimer's disease, schizophrenia, as well ...
Leurs, R. +3 more
openaire +2 more sources
Journal of Pharmacological Sciences, 2023 Histamine is a well-known inflammatory mediator, but how histamine induces angiogenesis remains poorly understood. In the present study, we demonstrated a dose-dependent dynamic tube formation in the human endothelial cell line EA.hy926 in the presence ...
Omer Faruk Hatipoglu +8 more
doaj +1 more source
Antihistaminergics and inverse agonism. Potential therapeutic applications [PDF]
, 2013 The accurate characterization of the molecular mechanisms involved in the action of receptor ligands is important for their appropriate therapeutic use and safety.
Davio, Carlos Alberto +4 more
core +13 more sources
Histamine H3 receptor antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats. [PDF]
Neuropsychiatr Dis Treat, 2019 Alachkar A +4 more
europepmc +3 more sources
Participation of Histamine H3 Receptors in Experimental Allergic Rhinitis of Mice
Journal of Pharmacological Sciences, 2008 The present study was performed to study the participation of histamine H3 receptors in nasal symptoms using Sch 50971, a potent and selective agonist of the H3 receptor.
Emiko Yokota +4 more
doaj +1 more source
Influence of the Novel Histamine H3 Receptor Antagonist/Inverse Agonist M39 on Gastroprotection and PGE2 Production Induced by (R)-Alpha-Methylhistamine in C57BL/6 Mice. [PDF]
Front Pharmacol, 2019 Bastaki SMA +4 more
europepmc +3 more sources
Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat [PDF]
, 2004 Background: In rat, deafferentation of one labyrinth (unilateral labyrinthectomy) results in a characteristic syndrome of ocular and motor postural disorders (e.g., barrel rotation, circling behavior, and spontaneous nystagmus). Behavioral recovery (e.g.,
Aarnisalo, Antti A. +4 more
core +2 more sources
Kv4.2 mediates histamine modulation of preoptic neuron activity and body temperature. [PDF]
PLoS ONE, 2011 Histamine regulates arousal, circadian rhythms, and thermoregulation. Activation of H3 histamine receptors expressed by preoptic GABAergic neurons results in a decrease of their firing rate and hyperthermia.
Jasmine Sethi +2 more
doaj +1 more source
Histamine, histamine H3 receptor, and alcohol use disorder. [PDF]
Br J Pharmacol, 2020 Peer ...
Panula P.
europepmc +3 more sources