Results 21 to 30 of about 12,080 (218)

Antihistaminergics and inverse agonism. Potential therapeutic applications [PDF]

, 2013
The accurate characterization of the molecular mechanisms involved in the action of receptor ligands is important for their appropriate therapeutic use and safety.
Davio, Carlos Alberto, Fernández, Natalia Brenda, Fitzsimons, Carlos, Monczor, Federico, Shayo, Carina Claudia   +4 more
core   +7 more sources

Histamine and migraine revisited: mechanisms and possible drug targets

The Journal of Headache and Pain, 2019
Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm, Katrine Falkenberg, Jes Olesen   +2 more
doaj   +1 more source

Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms [PDF]

, 2012
Although large cholangiocytes exert their functions by activation of cyclic adenosine 3',5'-monophosphate (cAMP), Ca(2+)-dependent signaling regulates the function of small cholangiocytes. Histamine interacts with four receptors, H1-H4HRs.
Fanyin Meng, FRANCHITTO, Antonio, GAUDIO, EUGENIO, Gianfranco D. Alpini, Guido Carpino, Hannah E. Shine, Heather L. Francis, Julie K. Venter, Kimberly K. Baker, MANCINELLI, ROMINA, Mellanie A. White, ONORI, PAOLO, RENZI, ANASTASIA, Sharon Demorrow, Taylor C. Francis, Yoshiyuki Ueno   +15 more
core   +1 more source

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease. [PDF]

, 2018
Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction.
Colwell, Christopher S, Cutler, Tamara, Howland, David, Loh, Dawn H, Wang, Huei-Bin, Whittaker, Daniel S   +5 more
core   +1 more source

Calyx and dimorphic neurons of mouse Scarpa's ganglion express histamine H3 receptors

BMC Neuroscience, 2009
Background Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. The site of action of these drugs however has not been elucidated yet.
Zucca Gianpiero, Zampini Valeria, Botta Laura, Tritto Simona, Valli Paolo, Masetto Sergio   +5 more
doaj   +1 more source

Methamphetamine- and 3,4-Methylenedioxymethamphetamine–Induced Behavioral Changes in Histamine H3–Receptor Knockout Mice

Journal of Pharmacological Sciences, 2009
Histamine H3 receptors inhibit the release of not only histamine itself, but also other neurotransmitters including dopamine. Previous papers have reported that histaminergic neurons inhibit psychostimulant-induced behavioral changes.
Tomohiro Okuda, Dongying Zhang, He Shao, Nobuyuki Okamura, Naoko Takino, Tatsunori Iwamura, Eiko Sakurai, Takeo Yoshikawa, Kazuhiko Yanai   +8 more
doaj   +1 more source

QSAR and Molecular Docking Studies on Non-Imidazole-Based Histamine H3 Receptor Antagonists [PDF]

Pharmaceutical Sciences, 2020
Background: In the recent years, histamine H3 receptor (H3R) has been receiving increasing attention in pharmacotherapy of neurological disorders.
Maryam Hamzeh-Mivehroud, Zoha Khoshravan-Azar, Siavoush Dastmalchi   +2 more
doaj   +1 more source

Role of Substance P on Histamine H3 Antagonist-Induced Scratching Behavior in Mice

Journal of Pharmacological Sciences, 2006
.: The purpose of the present study was to investigate the involvement of chemical mediators, other than histamine, in the scratching behavior induced by H3 antagonists.
Maria Alejandra Hossen, Toshio Inoue, Yoshifumi Shinmei, Yoko Fujii, Takeshi Watanabe, Chiaki Kamei   +5 more
doaj   +1 more source

Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]

, 2017
The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core   +3 more sources

Distribution and Modulation of Histamine H3 Receptors in Basal Ganglia and Frontal Cortex of Healthy Controls and Patients with Parkinson's Disease

Neurobiology of Disease, 2001
Parkinson's disease (PD) is a brain degenerative disorder with unknown etiology, and specific degeneration of mesencephalic dopaminergic cells is a morphological manifestation of the disease. The central histaminergic system appears to be activated in PD,
Oleg V. Anichtchik, Nina Peitsaro, Juha O. Rinne, Hannu Kalimo, Pertti Panula   +4 more
doaj   +1 more source