Results 41 to 50 of about 12,080 (218)

Histamine H3 Receptor Antagonists Go to Clinics

Biological and Pharmaceutical Bulletin, 2008
Within the recent years novel lead optimisations for histamine H(3) receptor antagonists made their way from bench to bedside. Structure-activity relationships, cross-affinities and side effects as well as pharmacokinetic profiling will be discussed on selected promising compound series.
Kerstin, Sander, Tim, Kottke, Holger, Stark   +2 more
openaire   +3 more sources

Therapeutic Approach of Histamine H3 Receptors in Obesity [PDF]

Recent Patents on CNS Drug Discovery, 2007
Obesity is considered one of the risk factors for metabolic disorders. There is increasing evidence that obesity is under control of several cytokines and hormone in the brain. Brain histamine and H3 receptors are important factors for regulating obesity.
Takayuki, Masaki, Hironobu, Yoshimatsu
openaire   +2 more sources

Transient changes in the limbic histaminergic system after systemic kainic acid-induced seizures

Neurobiology of Disease, 2005
Increased brain histamine is reported to protect against convulsions. We used systemic kainic acid (KA) administration to study possible changes of the histaminergic system in rat brain in status epilepticus (SE).
Minnamaija Lintunen, Tina Sallmen, Kaj Karlstedt, Pertti Panula   +3 more
doaj   +1 more source

Sites of action of sleep and wake drugs: insights from model organisms [PDF]

, 2013
Small molecules have been used since antiquity to regulate our sleep. Despite the explosion of diverse drugs to treat problems of too much or too little sleep, the detailed mechanisms of action and especially the neuronal targets by which these compounds
Rihel, J, Schier, AF
core   +1 more source

The Histamine H3 Receptor: Structure, Pharmacology, and Function [PDF]

Molecular Pharmacology, 2016
Among the four G protein-coupled receptors (H1-H4) identified as mediators of the biologic effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive expression in the nervous system and the large variety of isoforms generated by alternative splicing of the corresponding mRNA.
Gustavo, Nieto-Alamilla, Ricardo, Márquez-Gómez, Ana-Maricela, García-Gálvez, Guadalupe-Elide, Morales-Figueroa, José-Antonio, Arias-Montaño   +4 more
openaire   +2 more sources

Blocking Histamine H1 Improves Learning and Mnemonic Dysfunction in Mice With Social Isolation Plus Repeated Methamphetamine Injection

Journal of Pharmacological Sciences, 2008
The aim of this study was to investigate the effects of histamine H1 and H3 antagonists on learning and mnemonic dysfunction in mice. Two H1 antagonists, pyrilamine and clozapine, and the prototypic H3 antagonist thioperamide were used to study the role ...
Feiyong Jia, Jalal Izadi Mobarakeh, Hongmei Dai, Motohisa Kato, Ajing Xu, Tomohiro Okuda, Eiko Sakurai, Nobuyuki Okamura, Kazuhiro Takahashi, Kazuhiko Yanai   +9 more
doaj   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Histamine H3 Heteroreceptors Suppress Glutamatergic and GABAergic Synaptic Transmission in the Rat Insular Cortex

Frontiers in Neural Circuits, 2017
Histamine H3 receptors are autoreceptors that regulate histamine release from histaminergic neuronal terminals. The cerebral cortex, including the insular cortex (IC), expresses abundant H3 receptors; however, the functions and mechanisms of H3 receptors
Hiroki Takei, Hiroki Takei, Kiyofumi Yamamoto, Kiyofumi Yamamoto, Yong-Chul Bae, Tetsuo Shirakawa, Masayuki Kobayashi, Masayuki Kobayashi, Masayuki Kobayashi   +8 more
doaj   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is associated with several behavioral and cognitive symptoms, the neurobiological background of which is not yet fully understood. Objectives The aim was to investigate the association between monoamine function and four specific nonmotor symptoms in early PD using the Parkinson's Progression Markers ...
Kalle J. Niemi, Valtteri Kaasinen, Rimona S. Weil, Juho Joutsa   +3 more
wiley   +1 more source