Results 81 to 90 of about 13,967 (254)
Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer. [PDF]
PLoS ONE, 2014 We previously found that genetic polymorphisms in gene coding for histamine H4 receptors were related to the risk and malignant degree of breast cancer.
Gong-Hao He +7 more
doaj +1 more source
Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice [PDF]
, 2015 Histamine regulates release of neurotransmitters such as dopamine, serotonin, gamma-aminobutyric acid (GABA), glutamate and also is involved in several functions in central nervous system (CNS).
Alijanpour, Sakineh. +9 more
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Mediators of Inflammation, Volume 2026, Issue 1, 2026.Purpose Allergic conjunctivitis (AC) is a condition with a rising prevalence that occasionally leads to irreversible visual impairment. However, few novel therapeutic targets have been identified for AC. The investigation aims to utilize the Mendelian randomization (MR) technique to explore the causal impacts exerted by the plasma proteome on AC ...
Hao Li +6 more
wiley +1 more source
Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension
Advanced Science, Volume 12, Issue 45, December 4, 2025.H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi +18 more
wiley +1 more source
Frontiers in Systems Neuroscience, 2012 Histamine H3 receptor antagonists/ inverse agonists possess potential to treat diverse disease states of the central nervous system (CNS). Cognitive dysfunction and motor impairments are the hallmark of multifarious neurodegenerative and/or psychiatric ...
Divya eVohora, Malay eBhowmik
doaj +1 more source
Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein–Coupled Receptor Signaling [PDF]
, 2007 G protein–coupled receptors (GPCRs) exist in multiple dynamic states (e.g., ligand-bound, inactive, G protein–coupled) that influence G protein activation and ultimately response generation. In quantitative models of GPCR signaling that incorporate these
Kinzer-Ursem, Tamara L. +1 more
core +3 more sources
Narcolepsy: Pathophysiology, Diagnosis, Management, and Future Directions, a Narrative Review
Brain and Behavior, Volume 15, Issue 12, December 2025.This visual summary outlines the pathophysiology of narcolepsy, driven by hypocretin loss, and details its clinical diagnosis, current management strategies, and the shift toward future disease‐modifying therapies like orexin agonists and immunomodulation.
Natasha Elaine Hastings +12 more
wiley +1 more source
Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells
FEBS Open Bio, 2015 Pancreatic α‐cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α‐cells remains unknown.
Tadaho Nakamura +7 more
doaj +1 more source
Journal of Pharmacological Sciences, 2006 .: Histamine H3 receptors (H3Rs) are autoreceptors that negatively regulate the release of histamine and other neurotransmitters such as norepinephrine, dopamine, and acetylcholine in the central nervous system (CNS).
Tokita Shigeru +2 more
doaj +1 more source
Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review [PDF]
, 2019 Anorexia nervosa (AN) is a severe eating disorder affecting around 1 per 100 persons. However, the knowledge about its underlying pathophysiology is limited.
Schalla, Martha A., Stengel, Andreas
core +1 more source