Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands. [PDF]
PLoS ONE, 2019 In this study, we report a ligand-guided homology modeling approach allowing the analysis of relevant binding site residue conformations and the identification of two novel histamine H3 receptor ligands with binding affinity in the nanomolar range.
David Schaller +3 more
doaj +3 more sources
Plasticity of the histamine H3 receptors after acute vestibular lesion in the adult cat. [PDF]
Frontiers in Integrative Neuroscience, 2014 After unilateral vestibular neurectomy (UVN) many molecular and neurochemical mechanisms underlie the neurophysiological reorganizations occurring in the vestibular nuclei (VN) complex, as well as the behavioral recovery process.
Brahim eTighilet +2 more
doaj +2 more sources
Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease [PDF]
eLife, 2020 Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death.
David Moreno-Delgado +17 more
doaj +2 more sources
Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms. [PDF]
Nat Commun, 2014 AbstractThe role of the histamine H3 receptor (H3R) in cerebral ischaemia/reperfusion (I/R) injury remains unknown. Here we show that H3R expression is upregulated after I/R in two mouse models. H3R antagonists and H3R knockout attenuate I/R injury, which is reversed by an H3R-selective agonist.
Yan H +13 more
europepmc +5 more sources
Correlation of Histamine Receptors and Adrenergic Receptor in Broilers Appetite [PDF]
Archives of Razi Institute, 2022 The current study was conducted to investigate the interaction between the central adrenergic and histaminergic systems and the broiler chick’s feed intake.
M Daneshvar +3 more
doaj +1 more source
Loss of Melanopsin Photoreception and Antagonism of the Histamine H3 Receptor by Ciproxifan Inhibit Light-Induced Sleep in Mice [PDF]
, 2015 Light has direct effects on sleep and wakefulness causing arousal in diurnal animals and sleep in nocturnal animals. In the present study, we assessed the modulation of light-induced sleep by melanopsin and the histaminergic system by exposing mice to ...
Colas, Damien +4 more
core +14 more sources
Identification and characterization of ZEL-H16 as a novel agonist of the histamine H3 receptor. [PDF]
PLoS ONE, 2012 The histamine H3 receptor (H3R) has been recognized as a promising target for the treatment of various central and peripheral nervous system diseases.
Ying Shi +9 more
doaj +1 more source
Kv4.2 mediates histamine modulation of preoptic neuron activity and body temperature. [PDF]
PLoS ONE, 2011 Histamine regulates arousal, circadian rhythms, and thermoregulation. Activation of H3 histamine receptors expressed by preoptic GABAergic neurons results in a decrease of their firing rate and hyperthermia.
Jasmine Sethi +2 more
doaj +1 more source
Changes in Histamine Receptors (H1, H2, and H3) Expression in Rat Medial Vestibular Nucleus and Flocculus after Unilateral Labyrinthectomy: Histamine Receptors in Vestibular Compensation. [PDF]
PLoS ONE, 2013 Vestibular compensation is the process of behavioral recovery following peripheral vestibular lesion. In clinics, the histaminergic medicine is the most widely prescribed for the treatment of vertigo and motion sickness, however, the molecular mechanisms
Liuqing Zhou +6 more
doaj +1 more source
Interactions between Histamine H1 and H3 and Dopamine D1 Receptors on feeding behavior in chicken [PDF]
Iranian Journal of Veterinary Medicine, 2017 BACKGROUND: Brain monoamines (such as histamine and dopamine) play an important role in emotions, cognition, reward and feeding behavior. The interactions between histamine and dopamine were studied in many physiological functions but this correlation is
Masood GhandForoushan +2 more
doaj +1 more source