A Novel A1 Adenosine Receptor Antagonist, L-97-1 [3-[2-(4-Aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], Reduces Allergic Responses to House Dust Mite in an Allergic Rabbit Model of Asthma [PDF]
, 2005 Adenosine, an important signaling molecule in asthma, produces bronchoconstriction in asthmatics. Adenosine produces bronchoconstriction in allergic rabbits, primates, and humans by activating A1 adenosine receptors (ARs).
Batra, V. K. +5 more
core +1 more source
H3 antagonists and postoperative cognitive dysfunction
Journal of Anaesthesiology Clinical Pharmacology, 2019 Since histamine (HA) was first synthesized in 1907 and isolated as a bacterial contaminant of an extract of ergot in 1910, its role in health and disease and its molecular mechanism of action have been unraveled, leading to the formulation of an array of
Chandrasekhar Krishnamurti
doaj +1 more source
Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]
, 2015 Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David +17 more
core +1 more source
Mice in ecstasy : advanced animal models in the study of MDMA [PDF]
, 2010 The party drug 3,4-methylenedioxymethamphetamine -better known as MDMA or ecstasy- has numerous effects on the human body, characterized by a rush of energy, euphoria and empathy.
Stove, Christophe +3 more
core +2 more sources
Histaminosis alimentaria no alérgica (HANA) [PDF]
, 2016 En los últimos años se ha observado un creciente interés por las patologías relacionadas con la alimentación, ya sean procesos alérgicos, intolerancias alimentarias, sensibilidad o histaminosis.
Planas Prieto, Inés
core
Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review [PDF]
, 2019 Anorexia nervosa (AN) is a severe eating disorder affecting around 1 per 100 persons. However, the knowledge about its underlying pathophysiology is limited.
Schalla, Martha A., Stengel, Andreas
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Therapeutic potential of histamine H3 receptor agonists and antagonists
Trends in Pharmacological Sciences, 1998 The histamine H3 receptor was discovered 15 years ago, and many potent and selective H3 receptor agonists and antagonists have since been developed. Currently, much attention is being focused on the therapeutic potential of H3 receptor ligands. In this review, Rob Leurs, Patrizio Blandina, Clark Tedford and Henk Timmerman describe the available H3 ...
R. LEURS +3 more
openaire +5 more sources
Binding of the Dual-Action Anti-Parkinsonian Drug AG-0029 to Dopamine D2 and Histamine H3 Receptors: A PET Study in Healthy Rats. [PDF]
Mol Pharm, 2022 Ghazanfari N +13 more
europepmc +1 more source
The Histamine H3 Receptor and Eating Behavior
The Journal of Pharmacology and Experimental Therapeutics, 2011 Interest in the histaminergic system as a potential target for the treatment of feeding disorders is driven by the unsatisfactory history of the pharmacotherapy of obesity. Eating behavior is regulated by a complex interplay of central neurotransmitter systems, peripheral endocrine stimuli, the circadian rhythm, and environmental cues, all factors that
Passani, Maria Beatrice +2 more
openaire +5 more sources