Results 11 to 20 of about 10,224 (203)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Restless Legs Syndrome Associated With Fexofenadine Use: A Case Report. [PDF]

Clin Case Rep
Flowchart of possible fexofenadine‐induced RLS pathophysiology. ABSTRACT Restless legs syndrome (RLS) is a neurological sensorimotor disorder characterized by an irresistible urge to move the legs, typically worsening at night and leading to sleep disturbance.
Albeshry AM.
europepmc   +2 more sources

The histamine H3 receptor: from gene cloning to H3 receptor drugs [PDF]

Nature Reviews Drug Discovery, 2005
Since the cloning of the histamine H(3) receptor cDNA in 1999 by Lovenberg and co-workers, this histamine receptor has gained the interest of many pharmaceutical companies as a potential drug target for the treatment of various important disorders, including obesity, attention-deficit hyperactivity disorder, Alzheimer's disease, schizophrenia, as well ...
Leurs, R., Bakker, R.A., Timmerman, H., de Esch, I.J.P.   +3 more
openaire   +2 more sources

Interaction of Central Glutamatergic and Histaminergic Systems on Food Intake Regulation in Layer Chickens [PDF]

Archives of Razi Institute, 2021
This study purposed to discover the connection between the central glutamatergic and histaminergic systems on feeding behavior in layer chickens. In the first experiment, chicks obtained intracerebroventricular (ICV) injections of saline (control ...
M Mobarhan Fard, B Vazir, M Zendehdel, A Asghari   +3 more
doaj   +1 more source

Assessment of [125I]WYE-230949 as a novel histamine H3 receptor radiopharmaceutical. [PDF]

PLoS ONE, 2014
Histamine H3 receptor therapeutics have been proposed for several diseases such as schizophrenia, attention deficit hyperactivity disorder, Alzheimer's disease and obesity.
David Y Lewis, Sue Champion, David Wyper, Deborah Dewar, Sally Pimlott   +4 more
doaj   +1 more source

Histamine and migraine revisited: mechanisms and possible drug targets

The Journal of Headache and Pain, 2019
Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm, Katrine Falkenberg, Jes Olesen   +2 more
doaj   +1 more source

Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster [PDF]

, 2009
Nonhibernating seasonal mammals have adapted to temporal changes in food availability through behavioral and physiological mechanisms to store food and energy during times of predictable plenty and conserve energy during predicted shortage.
Bamshad, Barrett, Barrett, Brown, C. K. Song, D. Spanswick, D. Wilson, Doi, Enriori, Franklin, Franklin, Garcia, Gottsch, Inagaki, J. G. Mercer, Jamali, Jamali, Leurs, Liu, M. van den Top, Malmlöf, Morgan, Morgan, Morton, Nakamura, Nilaweera, Ookuma, P. Barrett, P. J. Morgan, Panula, Pillot, Prendergast, Revel, Ross, Sakata, Sallmen, Sallmen, Schneider, Song, Spanswick, Spanswick, T. J. Bartness, Top, Tups, Viguié, Yoshimoto, Yoshimura   +46 more
core   +1 more source

Calyx and dimorphic neurons of mouse Scarpa's ganglion express histamine H3 receptors

BMC Neuroscience, 2009
Background Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. The site of action of these drugs however has not been elucidated yet.
Zucca Gianpiero, Zampini Valeria, Botta Laura, Tritto Simona, Valli Paolo, Masetto Sergio   +5 more
doaj   +1 more source

Methamphetamine- and 3,4-Methylenedioxymethamphetamine–Induced Behavioral Changes in Histamine H3–Receptor Knockout Mice

Journal of Pharmacological Sciences, 2009
Histamine H3 receptors inhibit the release of not only histamine itself, but also other neurotransmitters including dopamine. Previous papers have reported that histaminergic neurons inhibit psychostimulant-induced behavioral changes.
Tomohiro Okuda, Dongying Zhang, He Shao, Nobuyuki Okamura, Naoko Takino, Tatsunori Iwamura, Eiko Sakurai, Takeo Yoshikawa, Kazuhiko Yanai   +8 more
doaj   +1 more source

QSAR study on the histamine (H3) receptor antagonists using the genetic algorithm: Multi parameter linear regression [PDF]

Journal of the Serbian Chemical Society, 2012
A quantitative structure activity relationship (QSAR) model has been produced for predicting antagonist potency of biphenyl derivatives as human histamine (H3) receptors. The molecular structures of the compounds are numerically represented by various
Adimi Maryam, Salimi Mahmoud, Nekoei Mehdi   +2 more
doaj   +1 more source