Therapeutic Approach of Histamine H3 Receptors in Obesity [PDF]
Recent Patents on CNS Drug Discovery, 2007 Obesity is considered one of the risk factors for metabolic disorders. There is increasing evidence that obesity is under control of several cytokines and hormone in the brain. Brain histamine and H3 receptors are important factors for regulating obesity.
Takayuki, Masaki, Hironobu, Yoshimatsu
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Mediators of Inflammation, 1995 The presence of histamine H3 receptors was evaluated on the rat aorta endothelium. In the presence of pyrilamine (1 nM, 7 nM, 10 nM) or thioperamide (1 nM, 10 nM, 30 nM) the concentration–response curve for histamine-induced (0.1 nM − 0.01 mM ...
D. M. Djuric, I. Z. Andjelkovic
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Медицинская иммунология, 2016 The study presents results concerning effects of H3/H4 histamine receptors antagonist (Ciproxifan) upon in vitro chemokine secretion by dendritic cells (DC) and peripheral blood mononuclear cells (PBMC).
V. S. Evstratova +3 more
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Drug design for CNS diseases: polypharmacological profiling of compounds using cheminformatic, 3D-QSAR and virtual screening methodologies [PDF]
, 2016 Support was kindly provided by the EU COST Action CM1103. DA, KN, and JV kindly acknowledge national project number 172033 and OI1612039 supported by the Ministry of the Republic of Serbia.
Agbaba, Danica +7 more
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Integrative role of the histaminergic system in feeding and taste perception
Frontiers in Systems Neuroscience, 2012 Feeding behavior is regulated by a complex interplay of many endogenous substances, such as peptides and neurotransmitters in the central nervous system.
Tomoko eIshizuka, Atsushi eYamatodani
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Cardiovascular effects of H3 histamine receptor inverse agonist/ H4 histamine receptor agonist, clobenpropit, in hemorrhage-shocked rats. [PDF]
PLoS ONE, 2018 Hemorrhagic shock has a potential to be life-threatening when it is not treated. The main causes of hemorrhagic shock involve: (1) forces causing injury; and (2) diseases that can cause hemorrhage., Therefore, due to the causes of hemorrhagic shock and ...
Bartosz Wanot +3 more
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The Histamine H3 Receptor: Structure, Pharmacology, and Function [PDF]
Molecular Pharmacology, 2016 Among the four G protein-coupled receptors (H1-H4) identified as mediators of the biologic effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive expression in the nervous system and the large variety of isoforms generated by alternative splicing of the corresponding mRNA.
Gustavo, Nieto-Alamilla +4 more
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Molecules, 2018 H3 receptors present on histaminergic and non-histaminergic neurons, act as autoreceptors or heteroreceptors controlling neurotransmitter release and synthesis.
Roman Guryn +6 more
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Identification of histaminic (H1-type) receptors in small intestine of broilers by application of histamine and some of its agonists and antagonists [PDF]
Veterinarski Glasnik, 2010 Histamine is a biologically active amine (biogenic amine) that has a broad spectra of physiologic and pathologic reactions in the organism. Its effects are shown through 4 types of specific receptors (H1, H2, H3 and H4).
Mujezinović Indira +3 more
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Heteroreceptor complexes formed by dopamine D1, histamine H3 and N-methyl-D-aspartate glutamate receptors as targets to prevent neuronal death in Alzheimer's disease [PDF]
, 2017 Alzheimer’s disease (AD) is a neurodegenerative disorder causing progressive memory loss and cognitive dysfunction. Anti-AD strategies targeting cell receptors consider them as isolated units. However, many cell surface receptors cooperate and physically
A Thathiah +50 more
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