Results 61 to 70 of about 10,224 (203)

Recent Advances in Molecular Pharmacology of the Histamine Systems: Physiology and Pharmacology of Histamine H3 Receptor: Roles in Feeding Regulation and Therapeutic Potential for Metabolic Disorders

Journal of Pharmacological Sciences, 2006
.: Histamine H3 receptors (H3Rs) are autoreceptors that negatively regulate the release of histamine and other neurotransmitters such as norepinephrine, dopamine, and acetylcholine in the central nervous system (CNS).
Tokita Shigeru, Takahashi Kazuhiko, Kotani Hidehito   +2 more
doaj   +1 more source

Histamine H(3) receptor-mediated signaling protects mice from cerebral malaria. [PDF]

PLoS ONE, 2009
BACKGROUND:Histamine is a biogenic amine that has been shown to contribute to several pathological conditions, such as allergic conditions, experimental encephalomyelitis, and malaria.
Walid Beghdadi, Adeline Porcherie, Bradley S Schneider, Séverine Morisset, David Dubayle, Roger Peronet, Michel Dy, Jacques Louis, Jean-Michel Arrang, Salaheddine Mécheri   +9 more
doaj   +1 more source

Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice [PDF]

, 2015
Histamine regulates release of neurotransmitters such as dopamine, serotonin, gamma-aminobutyric acid (GABA), glutamate and also is involved in several functions in central nervous system (CNS).
Alijanpour, Sakineh., Amini-Khoei, Hossein., Amiri, Shayan., Dehpour, Ahmad Reza., Ejtemaie Mehr, Shahram., Gooshe, Maziar., Haj-Mirzaian, Arya., Hassanipour, Mahsa., Rahimi-Balaei, Maryam., Shirzadian, Armin.   +9 more
core  

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells

FEBS Open Bio, 2015
Pancreatic α‐cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α‐cells remains unknown.
Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Attayeb Mohsen, Tomomitsu Iida, Yamato Miura, Akira Sugawara, Kazuhiko Yanai   +7 more
doaj   +1 more source

The involvement of central nervous system histamine receptors in psychological stress-induced exacerbation of allergic airway inflammation in mice

Allergology International, 2016
Background: Psychological stress is one of the major risk factors for asthma exacerbation. Although histamine in the brain acts as an excitatory and inhibitory neurotransmitter associated with psychological stress, the contribution of brain histamine to ...
Tomomitsu Miyasaka, Kaori Okuyama-Dobashi, Chiaki Masuda, Shunya Iwami, Miki Sato, Hirokazu Mizoguchi, Tasuku Kawano, Yuichi Ohkawara, Shinobu Sakurada, Motoaki Takayanagi, Isao Ohno   +10 more
doaj   +1 more source

Postsynaptic histamine H3 receptors in ventral basal forebrain cholinergic neurons modulate contextual fear memory

Cell Reports, 2023
Summary: Overly strong fear memories can cause pathological conditions. Histamine H3 receptor (H3R) has been viewed as an optimal drug target for CNS disorders, but its role in fear memory remains elusive.
Yanrong Zheng, Lishi Fan, Zhuowen Fang, Zonghan Liu, Jiahui Chen, Xiangnan Zhang, Yi Wang, Yan Zhang, Lei Jiang, Zhong Chen, Weiwei Hu   +10 more
doaj   +1 more source

Distribution and Modulation of Histamine H3 Receptors in Basal Ganglia and Frontal Cortex of Healthy Controls and Patients with Parkinson's Disease

Neurobiology of Disease, 2001
Parkinson's disease (PD) is a brain degenerative disorder with unknown etiology, and specific degeneration of mesencephalic dopaminergic cells is a morphological manifestation of the disease. The central histaminergic system appears to be activated in PD,
Oleg V. Anichtchik, Nina Peitsaro, Juha O. Rinne, Hannu Kalimo, Pertti Panula   +4 more
doaj   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source