Results 301 to 310 of about 98,227 (378)

The Immunology of Alpha‐Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat

open access: yesImmunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT The primary features of the alpha‐gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with infusions of Cetuximab are specific for galactose alpha‐1,3‐galactose. (ii) In the USA, this IgE ab is induced by bites of the tick Amblyomma americanum. (iii) The anaphylactic reactions to food derived from non‐primate mammals
Thomas A. E. Platts‐Mills   +3 more
wiley   +1 more source

ILC2 Diversity, Location, and Function in Pulmonary Disease

open access: yesImmunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT Type‐2 inflammation is driven by the production of canonical type‐2 cytokines IL‐4, IL‐5, and IL‐13. Type‐2 cytokines promote mucus production, innate immune cell recruitment, and smooth muscle contractility in mucosal tissues. These hallmarks of type‐2 inflammation are important contributors to the weep‐and‐sweep responses observed in the ...
Mukesh Verma   +2 more
wiley   +1 more source

Comparison of Dysautonomia Across Species: Current Knowledge and Future Research Opportunities

open access: yesJournal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Primary dysautonomia is a complex and often fatal autonomic nervous system disease. This literature review consolidates information on dysautonomia across species. Electronic databases (PubMed, Google Scholar and the Equine Grass Sickness Fund website) were systematically searched for veterinary and human medical literature on the topic.
Callum N. Atkins   +2 more
wiley   +1 more source

Clinical Characteristics and Outcomes of Patients With Rome IV Functional Dyspepsia Who Consume Opioids: A Real‐World Study

open access: yesNeurogastroenterology &Motility, Volume 37, Issue 7, July 2025.
Approximately one in three patients with Rome IV functional dyspepsia (FD) consume opioids and this is associated with older age, depression/anxiety, and chronic pain. Opioid cessation alongside a neuromodulator improved symptoms in 29% of cases, with a number needed to treat of 5.7, suggesting that this treatment strategy may be beneficial in FD ...
Mohsin F. Butt   +9 more
wiley   +1 more source

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

open access: yesThe FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source

Long‐term use of low‐dose aspirin for cancer prevention: A 20‐year longitudinal cohort study of 1,506,525 Hong Kong residents

open access: yesInternational Journal of Cancer, Volume 156, Issue 12, Page 2330-2339, 15 June 2025.
What's New? Low‐dose aspirin use over an extended period is associated with a reduced risk of colorectal cancer (CRC) and potentially other malignancies. Duration of use to derive such benefits, however, remains unclear. This retrospective study examined low‐dose aspirin use for possible chemoprotective effects among individuals in Hong Kong.
Amy Lam   +6 more
wiley   +1 more source

Lipid Metabolism and Immune Function: Chemical Tools for Insights into T‐Cell Biology

open access: yesChemBioChem, Volume 26, Issue 11, June 3, 2025.
This review explores how lipids regulate immune responses, particularly in T‐cell function. Advances in metabolomics and proteomics provide insights into lipid‐mediated immunity. Fluorescent lipids enable single‐cell analysis of lipid uptake and metabolism.
Luuk Reinalda   +2 more
wiley   +1 more source

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