Results 101 to 110 of about 190,274 (201)

Histiocytic sarcoma in dogs: epidemiology, anatomopathology, and immunohistochemistry [PDF]

Pesquisa Veterinária Brasileira
: Histiocytic sarcomas have been described in veterinary medicine since 1980, but studies on the subject are still scarce. Based on this, the objective of this article is to describe the epidemiological, anatomopathological and immunohistochemical ...
Flávia S. Da Luz, Renata D. Mazaro, Gabriela Hartmann, Tereza Cristina Da Silva, Bruno Cogliati, Lilian R. Marques de Sá, Glaucia D. Kommers, Alexandre A. Tonin, Rafael A. Fighera   +8 more
doaj   +1 more source

Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups

Haematologica, 2020
Histiocytic sarcoma is a rare malignant neoplasm that may occur de novo or in the context of a previous hematologic malignancy or mediastinal germ cell tumor.
Caoimhe Egan, Alina Nicolae, Justin Lack, Hye-Jung Chung, Shannon Skarshaug, Thu Anh Pham, Winnifred Navarro, Zied Abdullaev, Nadine S. Aguilera, Liqiang Xi, Svetlana Pack, Stefania Pittaluga, Elaine S. Jaffe, Mark Raffeld   +13 more
doaj   +1 more source

Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds.

PLoS Genetics, 2021
Histiocytic sarcoma is an aggressive hematopoietic malignancy of mature tissue histiocytes with a poorly understood etiology in humans. A histologically and clinically similar counterpart affects flat-coated retrievers (FCRs) at unusually high frequency,
Jacquelyn M Evans, Heidi G Parker, Gerard R Rutteman, Jocelyn Plassais, Guy C M Grinwis, Alexander C Harris, Susan E Lana, Elaine A Ostrander   +7 more
doaj   +1 more source

PTPN11 mutations in canine and human disseminated histiocytic sarcoma

International Journal of Cancer, 2020
In humans, histiocytic sarcoma (HS) is an aggressive cancer involving histiocytes. Its rarity and heterogeneity explain that treatment remains a challenge.
B. Hédan, Mélanie Rault, J. Abadie, R. Ulvé, Nadine Botherel, P. Devauchelle, C. Copie-Bergman, É. Cadieu, M. Parrens, J. Alten, Emmanuelle Lechapt Zalcman, G. Cario, G. Damaj, K. Mokhtari, François Le Loarer, A. Coulomb-Lherminé, T. Derrien, C. Hitte, L. Bachelot, M. Breen, D. Gilot, J. Blay, J. Donadieu, C. André   +23 more
semanticscholar   +1 more source

A case of canine cutaneous reactive histiocytosis over the body trunk in an adult pit bull terrier

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract The objective of this report is to present a case of canine cutaneous reactive histiocytosis with a high number of dendritic cells. A 7‐year‐old male pit bull terrier was presented with a 5‐month history of skin nodules and plaques on the trunk of varying diameter, along with corneal oedema and anterior uveitis.
Ioanna Papadogiannaki, Despoina Mourtzoukou, Konstantina Frangia, Emmanouil Papadogiannakis   +3 more
wiley   +1 more source

Repair of endogenous DNA base lesions modulate lifespan in mice [PDF]

, 2014
The accumulation of DNA damage is thought to contribute to the physiological decay associated with the aging process. Here, we report the results of a large-scale study examining longevity in various mouse models defective in the repair of DNA alkylation
Bronson, Roderick T., Calvo, Jennifer A., Klapacz, Joanna, Meira, Lisiane B., Moroski-Erkul, Catherine A., Samson, Leona D, Shah, Dharini   +6 more
core   +1 more source

The Clinicopathologic Spectrum of Rosai–Dorfman–Destombes Disease in Adults: An Analysis of 16 Cases

European Journal of Haematology, Volume 115, Issue 6, Page 555-564, December 2025.
ABSTRACT Rosai–Dorfman–Destombes disease (RDD) is a rare histiocytic proliferation with protean clinical manifestations, resulting from the accumulation of activated histiocytes within nodal and extra‐nodal tissues. The diagnosis can be missed, particularly when biopsies are obtained from extra‐nodal sites, where histological features may be less ...
Mark Trinder, Collin Pryma, Emily Leung, Graham W. Slack, Pedro Farinha, Sean Young, Neval Ozkaya, Mollie Carruthers, Luke Y. C. Chen   +8 more
wiley   +1 more source

Influence of Pretreatment Polarographically Measured Oxygenation Levels in Spontaneous Canine Tumors Treated with Radiation Therapy [PDF]

, 2018
Background and Purpose:: The level of hypoxia in primary tumors has been described to influence response to treatment. The aim of the present study was to investigate the impact of pretreatment oxygen level measurements in spontaneous canine tumors on ...
Achermann, Roger, Kaser-Hotz, Barbara, Ohlerth, Stefanie, Rohrer Bley, Carla, Roos, Malgorzata, Wergin, Melanie   +5 more
core  

A Genome Assembly-Integrated Dog 1 Mb BAC Microarray: A Cytogenetic Resource for Canine Cancer Studies and Comparative Genomic Analysis [PDF]

, 2010
Molecular cytogenetic studies have been instrumental in defining the nature of numerical and structural chromosome changes in human cancers, but their significance remains to be fully understood.
Breen, M., Duke, S. E., Ellis, P., Evans, A., Karlsson, Elinor Kathryn, Langford, C.F., Lindblad-Toh, K., Thomas, R.   +7 more
core   +3 more sources

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

Angewandte Chemie International Edition, Volume 64, Issue 48, November 24, 2025.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source