Results 21 to 30 of about 190,274 (201)

Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma

Scientific Reports, 2023
Histiocytic sarcoma (HS) is an incurable aggressive tumor, and no consensus has been made on the treatment due to its rare occurrence. Since dogs spontaneously develop the disease and several cell lines are available, they have been advocated as ...
Hajime Asada, Akiyoshi Tani, Hiroki Sakuma, Miyuki Hirabayashi, Yuki Matsumoto, Kei Watanabe, M. Tsuboi, Shino Yoshida, K. Harada, Takao Uchikai, Y. Goto-Koshino, J. Chambers, Genki Ishihara, Tetsuya Kobayashi, M. Irie, K. Uchida, K. Ohno, M. Bonkobara, H. Tsujimoto, H. Tomiyasu   +19 more
semanticscholar   +1 more source

Case report: Targeting the PD-1 receptor and genetic mutations validated in primary histiocytic sarcoma with hemophagocytic lymphohistiocytosis

Frontiers in Immunology, 2023
Histiocytic sarcoma (HS) is a rare hematological malignancy with limited treatment options, and it is also prone to complications such as hemophagocytic lymphohistiocytosis (HLH) in the later stages of the disease, leading to difficulties in treatment ...
Yan Zhao, Yating Deng, Yi Jiang, Wenli Zheng, Yanlin Tan, Zhiwu Yang, Zhihua Wang, Feng Xu, Zhao Cheng, Lingli Yuan, Hongling Peng   +10 more
semanticscholar   +1 more source

Transdifferentiation of B‐lymphoblastic leukemia to histiocytic sarcoma after immunotherapy

American journal of hematology/oncology, 2023
To the Editor: Anti-CD19 chimeric antigen receptors (CAR) T cells are used to treat relapsed/refractory B-lymphoblastic leukemia (B-ALL). Tumor escape can occur by target antigen loss, and myeloid lineage switch in KMT2A or ZNF384-rearranged B-ALL. Here,
E. Fenu, Elizabeth M Margolskee, Vinodh Pillai   +2 more
semanticscholar   +1 more source

The two main forms of histiocytic sarcoma in the predisposed Flatcoated retriever dog display variation in gene expression. [PDF]

PLoS ONE, 2014
Examination of gene functions in specific tumor types improves insight in tumorigenesis and helps design better treatments. Due to the rarity of histiocytic/dendritic cell sarcoma in humans, it is difficult to accrue such knowledge.
Kim M Boerkamp, Frank G van Steenbeek, Louis C Penning, Marian J A Groot Koerkamp, Dik van Leenen, Manon Vos-Loohuis, Guy C M Grinwis, Gerard R Rutteman   +7 more
doaj   +1 more source

Utility of the second-generation curcumin analogue RL71 in canine histiocytic sarcoma

Veterinary research communications, 2023
Canine histiocytic sarcoma is an aggressive cancer, with a high rate of metastasis. Thus, novel therapeutic approaches are needed. Synthetic analogues of curcumin have elicited potent anti-cancer activity in multiple in vitro and in vivo models of human ...
Barnaby Kelly, D. Thamm, R. Rosengren
semanticscholar   +1 more source

Histiocytic sarcoma in renal transplant patients: a literature review

Journal of Medical Case Reports, 2023
Background Histiocytic sarcoma (HS) is defined as neoplasm resembling morphological and immunophenotypic characteristics of mature histiocytes. It is a rare form of lymphoid neoplasms.
Mahsa Salehi, Shafi Rehman, Miraa Qutab, Ruba Altheeb, Rashmi Prakash, Hamid Reza Jafari   +5 more
doaj   +1 more source

Histiocytic Sarcoma of Tibia: A Rare Case Report and Review of Literature

South Asian Journal of Cancer, 2022
Ajita Kendre Histiocytic sarcoma is a rare disorder and there has been a lot of confusion and debate regarding its diagnosis and treatment.
Ajita Kendre, Bhooshan Zade, Prasant Chandra   +2 more
doaj   +1 more source

Histiocytic Sarcoma: Clinical Features and Outcomes of Patients Treated at a Tertiary Cancer Care Center

Cureus, 2022
Histiocytic sarcoma (HS) is an extremely rare histiocytic disorder of unknown etiology. It is not a true sarcoma and is named so, due to the pathological resemblance to mature histiocytes.
Deepa Susan Joy Philip, Amitha Sherief, G. Narayanan, S. Nair, Jayasudha Av   +4 more
semanticscholar   +1 more source

Lymph node recurrence and re-excision after primary tumor resection of a histiocytic sarcoma of duodenal origin: a case report

Surgical Case Reports, 2022
Background Histiocytic sarcoma is a rare malignant tumor that is similar in characteristics to a mature histiocyte/macrophage and is a relatively new disease entity.
Kohei Segami, Shinjiro Kobayashi, Masaki Hiwatari, Yuta Ogura, Masafumi Katayama, Satoshi Koizumi, Motohiro Chosokabe, Junki Koike, Takehito Otsubo   +8 more
doaj   +1 more source

Application of PD-L1 blockade in refractory histiocytic sarcoma: A case report

Molecular and clinical oncology, 2022
Histiocytic sarcoma (HS) is a rare hematological malignancy, which exhibits morphological and immunophenotypic features of histiocytes. A standard therapy for HS has not yet been established due to its rareness; therefore, disease control is not always ...
O. Imataki, Makiko Uemura, Haruyuki Fujita, N. Kadowaki   +3 more
semanticscholar   +1 more source