Results 51 to 60 of about 5,123 (202)

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

Angewandte Chemie International Edition, EarlyView.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

Combined Tumors in Hematolymphoid Neoplasms: Case Series of Histiocytic and Langerhans Cell Sarcomas Arising From Low-Grade B-Cell Lymphoma

Clinical Pathology, 2019
We report an index case of histiocytic sarcoma arising in a 70-year-old patient with long-standing chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The patient presented in 2017 with painful, enlarging swelling of the left neck.
Stephanie L Skala, Jing C Ye, Jennifer Stumph, William R Macon, Frances R Quinones, Vadim Khachaturov, Rhett P Ketterling, Rajan Dewar   +7 more
doaj   +1 more source

Primary brain involvement of disseminated histiocytic sarcoma in a Rottweiler dog - histopathology, 18F-fluorodeoxyglucose positron emission tomography and 7 T-magnetic resonance imaging findings: a case report

Veterinární Medicína, 2017
An eight-year-old, intact male Rottweiler dog was presented due to anorexia, lethargy, ataxia and imbalance. Cerebellar and thyroid masses were identified using 0.3T magnetic resonance imaging.
B.T. Kang, D. An, H.W. Kim, Y. Jin, Y.D. Son, D.I. Jung, J.H. Kang, M.P. Yang, J.H. Sur, S.R. Lee   +9 more
doaj   +1 more source

Clinicopathologic, immunohistochemical, and ultrastructural features of histiocytic sarcoma in a chinchilla (Chinchilla lanigera)

Veterinary Medicine and Science, 2022
A 9‐year‐old intact female chinchilla (Chinchilla lanigera) was presented to a referring veterinarian due to small, multiple cervical nodules that had been rapidly increasing in size and number.
Kaoru Enomoto, Chihiro Tsutsumitani, Midori Goto Asakawa   +2 more
doaj   +1 more source

Some epidemiological characteristics of malignant fibrous histiocytoma in the Province of Vojvodina [PDF]

, 2005
BACKGROUND: Malignant fibrous histiocytoma is most common soft tissue sarcoma occurring in late adult life, most in the extremities and in the retroperitoneum, usually developing in deep fascia or skeletal muscle.
Dugandžija Tihomir, Nikolin Borislava L., Salma Svetlana, Trifunović Jasna, Vojnović Dragana   +4 more
core   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

Histiocytic Sarcoma of the Bile Duct

Internal Medicine, 2014
An 80-year-old man was admitted with anorexia, a high fever and general icterus. Laboratory examinations revealed remarkable inflammation and elevation of liver/biliary enzymes. Computed tomography (CT) showed a high-density lesion in the bile duct, and endoscopic retrograde cholangiopancreatography (ERCP) disclosed an oval filling defect mimicking ...
Hiroaki Yamashita, Hiroshi Inagaki, Tomoaki Ando, Michihiro Yoshida, Itaru Naitoh, Takahiro Nakazawa, Takashi Joh, Shuya Shimizu, Hiromu Kondo, Fumihiro Okumura, Kazuki Hayashi, Yan Ge, Ayako Masaki, Shuichiro Umemura, Katsuyuki Miyabe, Hirotaka Ohara, Yasuki Hori   +16 more
openaire   +4 more sources

CCNU for the Treatment of Dogs with Histiocytic Sarcoma [PDF]

Journal of Veterinary Internal Medicine, 2007
Background: Histiocytic sarcoma is an aggressive neoplasm of dendritic cells that carries a grave prognosis. The efficacy of chemotherapy against this disease is unknown. The purpose of this study was to determine the efficacy of 1‐(2‐chloroethyl)‐3‐cyclohexyl‐1‐nitrosourea (CCNU) in dogs with incompletely resected or metastatic histiocytic sarcoma, to
Karin U. Sorenmo, Michael S. Kent, Craig A. Clifford, Aarti Sabhlok, Katherine A Skorupski, Lisa G. Barber, Elizabeth A. Mauldin, Amy K. LeBlanc, Ana Lara-Garcia, Melissa Paoloni, Frances S. Shofer, C. Guillermo Couto   +11 more
openaire   +2 more sources

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

Langerhans´cell histiocytosis [PDF]

, 2014
La histiocitosis de células de Langerhans (HCL), anteriormente conocida como histiocitosis X, es una enfermedad poco frecuente caracterizada por la acumulación y proliferación de histiocitos, eosinófilos y células de Langerhans, con inclusión de gránulos
Casanovas, A., Elena, G., Rosso, Diego
core   +1 more source