Results 51 to 60 of about 5,434 (165)

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

An unusual case of giant cell tumor of soft parts in an American Warmblood horse [PDF]

Open Veterinary Journal, 2019
Fine needle aspiration and tissue biopsy samples were taken from a subcutaneous mass in the cranial stifle region of a 10-year-old horse. Key cytologic features included: numerous mildly to moderately pleomorphic histiocytic cells admixed with ...
Kurt Zimmerman, Frederic Almy, Geoff Saunders, Mark Crisman, Leonardo Leonardi   +4 more
doaj   +1 more source

Genetic analysis of primary lung interdigitating dendritic cell sarcomas

The Journal of Pathology, Volume 269, Issue 4-5, Page 387-398, August 2026.
Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov, Juliana Faria Filipe, Sylvia Eidenhammer, German Ott, Iris Halbwedl, Karl Kashofer, Helmut Popper   +6 more
wiley   +1 more source

Testicular histiocytic sarcoma: a case report and literature review of an uncommon histological type of urogenital malignancy

BMC Urology
Background Testicular tumors are relatively uncommon urogenital malignancies, accounting for only 1–2% of all cancers in men, with germ cell tumors representing the predominant histopathological subtype.
Houyi Wei, Zhixiu Cao, Yipeng Liu, Suibin Huang, Tao Bai, Lei Lyu, Jingdong Yuan   +6 more
doaj   +1 more source

Unilateral ductus deferens aplasia with terminal cystic dilation in a Bernese mountain dog

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract An incidental caudal abdominal mass was discovered in a 5‐year‐old, male, entire Bernese mountain dog. Investigations showed a terminal cystic dilation of the left ductus deferens. Castration, along with surgical resection of the mass, was performed, and histopathology of the mass and ductus deferens was consistent with segmental aplasia of ...
Daisy Johnson, Louisa Price, Marie Beales, Joanna Stephenson   +3 more
wiley   +1 more source

Splenic lymphoid hyperplasia in a cat presenting with hyperammonaemia, hypercalcaemia and hypercobalaminaemia

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract A 5‐year‐old, male neutered, Bengal‐cross cat presented with progressive neurological signs (ataxia and torticollis). Initial haematology, serum biochemistry and electrolytes (including calcium) were unremarkable; however, ammonia was markedly elevated.
Kerry E. Rolph, Tim Scase, Owen Davies
wiley   +1 more source

What Is Your Diagnosis? Multiple Subcutaneous Lumps in a Horse

Veterinary Clinical Pathology, EarlyView.
Federica Meistro, Maria Virginia Ralletti, Riccardo Rinnovati, Alessandro Spadari, Maria Morini   +4 more
wiley   +1 more source

Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom

British Journal of Haematology, Volume 209, Issue 2, Page 747-754, August 2026.
Trametinib (MEK inhibitor) shows efficacy in refractory and high‐risk adult histiocytic neoplasms. At a median follow‐up of 21.4 months, the clinical response rate was 81% (30/37) and the radiological response was 68% (25/37) (n = 37).
Rodothea Amerikanou, Talha Munir, Kristian Bowles, Christopher McNamara, Nikesh Chavda, Elizabeth Price, Jagdish Adiyodi, Alasdair Coles, Philippa Kelsey, Jeffery Smith, Richard Adams, Hayder Hussein, Rui Zhao, Trung Nguyen, Matthew Collin, Satyen Gohil   +15 more
wiley   +1 more source

What Is Your Diagnosis? Abnormal WNR Scattergram From the Sysmex XN‐1000V in a Dog

Veterinary Clinical Pathology, EarlyView.
Javier Martínez‐Caro, Marta Lemos, Albert Lloret, Josep Pastor   +3 more
wiley   +1 more source

Histiocytic sarcoma in dogs: epidemiology, anatomopathology, and immunohistochemistry [PDF]

Pesquisa Veterinária Brasileira
: Histiocytic sarcomas have been described in veterinary medicine since 1980, but studies on the subject are still scarce. Based on this, the objective of this article is to describe the epidemiological, anatomopathological and immunohistochemical ...
Flávia S. Da Luz, Renata D. Mazaro, Gabriela Hartmann, Tereza Cristina Da Silva, Bruno Cogliati, Lilian R. Marques de Sá, Glaucia D. Kommers, Alexandre A. Tonin, Rafael A. Fighera   +8 more
doaj   +1 more source