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Blood, 2020 Langerhans Cell Histiocytosis (LCH) is caused by clonal expansion of myeloid precursors that differentiate into CD1a+/CD207+ cells in lesions that leads to a spectrum of organ involvement and dysfunction.
Carlos Rodriguez-Galindo, Carl E Allen
exaly +2 more sources
New England Journal of Medicine, 2018 Langerhans cell histiocytosis (LCH) formerly known as pulmonary eosinophilic granuloma is currently regarded by the World Health Organization as a clonal neoplastic proliferation of histiocytes.
Carl E Allen +2 more
exaly +2 more sources
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Loss-of-function of ENT3 drives histiocytosis and inflammation through TLR-MAPK signaling.
Blood, 2023Histiocytoses are inflammatory myeloid neoplasms often driven by somatic activating mutations in mitogen-activated protein kinase (MAPK) cascade genes.
Ruth Shiloh +23 more
semanticscholar +1 more source
Langerhans cell histiocytosis in adults: Advances in pathophysiology and treatment
Cancer Science, 2018 Langerhans cell histiocytosis (LCH) is a rare systemic disorder characterized by the accumulation of CD1a+/Langerin+ LCH cells and wide‐ranging organ involvement.
Masayuki Kobayashi, Arinobu Tojo
exaly +2 more sources
Medicina Clínica, 2023
Histiocytosis is a group of rare diseases characterized by inflammation and accumulation of cells derived from monocytes and macrophages in different tissues. The symptoms are highly variable, from mild forms with involvement of a single organ to severe multisystem forms that can be life compromising.
Gemma, Rocamora-Blanch +2 more
openaire +2 more sources
Histiocytosis is a group of rare diseases characterized by inflammation and accumulation of cells derived from monocytes and macrophages in different tissues. The symptoms are highly variable, from mild forms with involvement of a single organ to severe multisystem forms that can be life compromising.
Gemma, Rocamora-Blanch +2 more
openaire +2 more sources
Radiographics, 2021
Histiocytosis is a rare inflammatory process characterized by pathologic infiltration and accumulation of cells derived from the monocytic lineage in normal tissue.
K. Huynh, B. Nguyen
semanticscholar +1 more source
Histiocytosis is a rare inflammatory process characterized by pathologic infiltration and accumulation of cells derived from the monocytic lineage in normal tissue.
K. Huynh, B. Nguyen
semanticscholar +1 more source