Results 311 to 320 of about 108,384 (342)

Unaltered class II histocompatibility antigens and pathogenesis of IDDM in BB rats

Diabetes, 1989
The BB rat spontaneously develops insulin-dependent diabetes mellitus (IDDM) as an autoimmune abnormality involving the class II molecules of the major histocompatibility complex (MHC). The rat MHC (RT1 complex) encodes two class II loci, RT1 .B and RT1.D.
E W, Holowachuk, M K, Greer
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Expression of class I and class II major histocompatibility complex antigens on human hepatocytes

Hepatology, 1988
We analyzed whether normal human hepatocytes, which normally do not display Class II major histocompatibility complex antigens, can be induced to express them in vitro, and whether this induction has an in vivo counterpart in chronic liver diseases.
A. Franco, BARNABA, Vincenzo, Piergiorgio Natali, Clara Balsano, Antonino Musca, Francesco Balsano   +5 more
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Interferon-induced expression of class II major histocompatibility antigens in the major histocompatibility complex (MHC) class II deficiency syndrome

Journal of Clinical Immunology, 1988
Class II antigens encoded by genes of the major histocompatibility complex (MHC) are expressed by a variety of cell types and have a vital role in the cellular interactions required for an effective immune response. We have analyzed the regulation of HLA-DR, DP, and DQ class II antigen expression on cells of different lineage from an immunodeficient ...
S, Plaeger-Marshall, A, Haas, L T, Clement, J V, Giorgi, I S, Chen, S G, Quan, R A, Gatti, E R, Stiehm   +7 more
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Expression of major histocompatibility complex class II antigens in the canine intestine

Veterinary Immunology and Immunopathology, 1998
Immunohistochemical techniques were used to assess major histocompatibility complex (MHC) class II expression by enterocytes and lamina propria cells in the canine intestinal tract. Duodenal enterocyte class II expression was faint and limited to the lower crypt region whereas jejunal and ileal enterocyte expression was stronger, being present in both ...
A J, German, P W, Bland, E J, Hall, M J, Day   +3 more
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Peptide binding and antigen presentation by class II histocompatibility glycoproteins

Biopolymers, 1997
The immune system has evolved complex mechanisms for the recognition and elimination of pathogens. CD4+ helper T lymphocytes play a central role in orchestrating immune responses and their activation is carefully regulated. These cells selectively recognize short peptide antigens stably associated with membrane-bound class II histocompatibility ...
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Structure and Polymorphism of Murine and Human Class II Major Histocompatibility Antigens

Immunological Reviews, 1985
The molecular analysis of the Class II region of the MHC of mice and of humans has to date led to some important conclusions. These regions encode sizeable families of related loci, at least 2 alpha and 6 beta in mice and 6 alpha and 7 beta in man. In addition to the sizeable number of potential molecules that could be expressed by the loci of this ...
J I, Bell, D W, Denny, H O, McDevitt
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Class II major histocompatibility antigens and the etiology of systemic lupus erythematosus

Clinical Immunology and Immunopathology, 1983
It is hypothesized that the underlying immunoregulatory dysfunction in systemic lupus erythematosus (SLE) is altered recognition by T cells of self class II major histocompatibility antigens (Ia). The resultant cellular autoreactivity would directly cause certain of the immunopathological manifestations of SLE. The perception by T cells of self non-MHC
R A, Eisenberg, P L, Cohen
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ALLOSPECIFIC MONOCLONAL ANTIBODIES RECOGNIZING RAT CLASS I AND CLASS II HISTOCOMPATIBILITY ANTIGENS

Transplantation, 1982
Rat-mouse hybridomas have been developed producing monoclonal antibodies which recognize rat major histocompatibility complex specificities. Splenic lymphocytes from a LEW (RT1l) rat alloimmunized against ACI (Rt1a) splenocytes were used for hybridoma production.
E E, Engel, R D, Guttmann, A, Fuks
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Biosynthesis and processing of class II histocompatibility antigens.

Critical reviews in immunology, 1987
The class II major histocompatibility antigens at the cell surface exist as heterodimers of alpha and beta subunits. During biosynthesis, these subunits are associated with a third chain, the invariant (I) or I chain. Association with the I chain occurs early in biosynthesis in the rough endoplasmic reticulum and persists during transport through the ...
P, Cresswell, J S, Blum, D N, Kelner, M S, Marks   +3 more
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Studies on the Interaction of T Cells with Major Histocompatibility Complex Class II Antigens

Clinical Science, 1995
1. Major histocompatibility complex class II antigens have the central role in the immune response of ‘presenting’ antigenic peptide to CD4+ T-cells. This interaction with a T-cell's receptor may result in activation, but, if recognition occurs without collateral molecular interactions which cause ‘co-stimulation’, these T-cells will be tolerized.
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