Results 321 to 330 of about 453,877 (390)

Revolutionising Cancer Immunotherapy: Advancements and Prospects in Non‐Viral CAR‐NK Cell Engineering

Cell Proliferation, Volume 58, Issue 4, April 2025.
This manuscript provides a comprehensive overview of the state‐of‐the‐art in non‐viral CAR‐NK cell engineering, highlighting its potential to revolutionise cancer treatment. ABSTRACT The recent advancements in cancer immunotherapy have spotlighted the potential of natural killer (NK) cells, particularly chimeric antigen receptor (CAR)–transduced NK ...
Zhaokai Zhou, Yifeng Chen, Yuhao Ba, Hui Xu, Anning Zuo, Shutong Liu, Yuyuan Zhang, Siyuan Weng, Yuqing Ren, Peng Luo, Quan Cheng, Lulu Zuo, Shanshan Zhu, Xing Zhou, Chuhan Zhang, Yukang Chen, Xinwei Han, Teng Pan, Zaoqu Liu   +18 more
wiley   +1 more source

The MHC (Major Histocmpatibility Complex) Exceptional Molecules of Birds and Their Relationship to Diseases. [PDF]

Int J Mol Sci
Arnaiz-Villena A, Suarez-Trujillo F, Ruiz-Del-Valle V, Juarez I, Vaquero-Yuste C, Martin-Villa JM, Lledo T.   +6 more
europepmc   +1 more source

Class II histocompatibility antigens (HLA) in childhood adrenocortical tumors (act): low expression is related with poor prognosis [PDF]

, 2012
Fabiola Arruda Leite, Régia Caroline Peixoto Lira, Paola Fernades Fedatto, Carlos Eduardo Martinelli, Sonir Roberto Rauber Antonini, Margaret de Castro, Sílvio Tucci, Luciano Neder, Leandra Naíra Zambelli Ramalho, Ana Luíza Seidinger, Izilda Aparecida Cardinalli, Maria José Mastellaro, José Andres Yunes, Sílvia Regina Brandalise, Luíz Gonzaga Tone, Carlos Alberto Scrideli   +15 more
openalex  

Genetically Engineered Hypoimmune Human Muscle Progenitor Cells Can Reduce Immune Rejection

Cell Proliferation, Volume 58, Issue 4, April 2025.
Cells face two challenges after transplantation: recognition and killing by lymphocytes, and cell apoptosis induced by the transplantation environment. Our hypoimmune cells aim to address these two challenges through editing of immunomodulatory proteins and overexpression of anti‐apoptotic proteins.
Yu Chen, Peng Wang, Shilin Ma, Chenran Yue, Xupeng Liu, Yeqian Cheng, Kun Liu, Tongbiao Zhao, Ng Shyh‐Chang   +8 more
wiley   +1 more source

Prolonging calcineurin inhibitor therapy post kidney allograft failure: a prospective study. [PDF]

Ren Fail
Leal R, Fragoso P, Venda J, Gomes J, Inácio M, Guedes Marques M, Rodrigues L, Santos L, Romãozinho C, Caramelo F, Sá HO, Martinho A, Figueiredo A, Alves R.   +13 more
europepmc   +1 more source

PD‐L1 Promotes Immunological Tolerance and Enhances Visual Protection of hESC‐RPE Grafts in Retinal Degeneration

Cell Proliferation, EarlyView.
We generated immune‐tolerant mature hESC‐RPE cells by overexpressing PD‐L1. PD‐L1‐expressing hESC‐RPE grafts exhibited significantly higher survival, reduced apoptosis and enhanced visual protection in retinal degeneration models, which presents an alternative target to improve the efficiency of hESC‐RPE‐based therapy for AMD. ABSTRACT Immune rejection
Bowen Li, Xue Zhang, Yajie Fang, Min Chen, Qiyou Li, Yuxiao Zeng, Chunge Ren, Chengang Wang, Yingxue Lv, Jia Lu, Hongling Liu, Yong Liu   +11 more
wiley   +1 more source

Molecular matching tools for allocation and immunosuppression optimization. Ready for primetime? [PDF]

Curr Opin Organ Transplant
Niemann M, Matern BM.
europepmc   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Advancing risk stratification in kidney transplantation: integrating HLA-derived T-cell epitope and B-cell epitope matching algorithms for enhanced predictive accuracy of HLA compatibility. [PDF]

Front Immunol
Niemann M, Matern BM, Gupta G, Tanriover B, Halleck F, Budde K, Spierings E.   +6 more
europepmc   +1 more source

Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis

Cell Proliferation, EarlyView.
Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu, Weihao Li, Liujing Zhuang, Jinxia Liu, Ping Wang, Ye Gu, Yongliang Liu, Yiqun Yu   +7 more
wiley   +1 more source