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Major Histocompatibility Complex Class II Antigen Presentation in Hodgkin's Disease
Leukemia & Lymphoma, 1999The malignant cells in Hodgkin's disease (HD), commonly referred to as Hodgkin and Reed-Sternberg (HRS) cells, express major histocompatibility complex (MHC) class II molecules and, like "professional" antigen-presenting cells (APCs), different accessory or costimulatory molecules which can provide an additional activation signal to T cells.
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Expression of Major Histocompatibility Complex Class II Antigens in Porcine Leptospiral Nephritis
Veterinary Pathology, 2009Class II major histocompatibility complex (MHCII) is required for the presentation of antigens to CD4 helper T cells. During nephritis, not only primary antigen presenting cells such as histiocytes and lymphocytes, but also cytokine-stimulated tubular epithelial cells express MHCII.
E. Radaelli +8 more
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Processing and Presentation of Antigen by the Class II Histocompatibility System
20101 Introduction 2 The Innate System of Defense, APCs, and Symbiosis with T Cells 3 Antigen Presentation in Thymus and Peripheral Lymphoid Organs 4 MHCII Molecules 5 Stages in Antigen Presentation 6 APC Interactions with T Cells Keywords: innate system of defense, APCs, and T cell symbiosis; antigen presentation in thymus ...
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Class II Antigens of the Human Major Histocompatibility Complex
1987Progress in the biological sciences has been remarkable during the past several decades. As the level of sophisticated knowledge expands it becomes difficult if not impossible for the individual investigator to master but a tiny segment of current biology.
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Class II histocompatibility antigens on human dendritic cells.
Immunology, 1987Histocompatibility antigens of the HLA D locus on the surface of human dendritic cells (DC) were visualized in the electron microscope using immunogold labelling. DC from peripheral blood expressed DR that was frequently concentrated at junctions between aggregating DC and lymphocytes or DC and macrophages.
S C, Knight +3 more
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Differential expression of major histocompatibility complex class II antigens on human keratinocytes
Journal of the American Academy of Dermatology, 1988Skin biopsies from 136 patients with 30 different dermatoses and eight biopsies of normal skin were investigated with the avidin-biotin-peroxidase complex method with regard to the expression of major histocompatibility complex class II antigens human leukocyte antigen (HLA) HLA-DR, HLA-DQ, HLA-DP on keratinocytes.
H, Niedecken +3 more
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International Journal of Dermatology, 1994
Abstract Background. Expression of various class II MHC antigens by lesional keratinocytes may play an important role in the pathophysiology of a wide variety of human dermatoses including cutaneous T cell lymphoma (CTCL). Nevertheless, there is relatively little information available concerning the concurrent expression of HLA‐DR, ‐DP, and ‐DO class ...
G S, Wood +4 more
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Abstract Background. Expression of various class II MHC antigens by lesional keratinocytes may play an important role in the pathophysiology of a wide variety of human dermatoses including cutaneous T cell lymphoma (CTCL). Nevertheless, there is relatively little information available concerning the concurrent expression of HLA‐DR, ‐DP, and ‐DO class ...
G S, Wood +4 more
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Methods in enzymology, 2009
Major histocompatibility complex (MHC) class I and II molecules can both present cytosolic and nuclear antigens to CD8(+) and CD4(+) T cells, respectively. However, MHC class I displays proteasomal, whereas MHC class II molecules display lysosomal, degradation products. One pathway by which intracellular antigens gain access to lysosomal degradation is
Gannagé, M, Münz, C
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Major histocompatibility complex (MHC) class I and II molecules can both present cytosolic and nuclear antigens to CD8(+) and CD4(+) T cells, respectively. However, MHC class I displays proteasomal, whereas MHC class II molecules display lysosomal, degradation products. One pathway by which intracellular antigens gain access to lysosomal degradation is
Gannagé, M, Münz, C
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Intrathyroidal Mast Cells Express Major Histocompatibility Complex Class-II Antigens
International Archives of Allergy and Immunology, 1989We studied the expression of major histocompatibility complex (MHC) class-II antigen in mast cells of rat thyroid glands. In the normal rat thyroid, mast cells express MHC class-II antigen. In BioBreeding Wistar (BB/W) rats, the strain of animals prone to develop spontaneous autoimmune thyroiditis, the number of MHC class-II-positive mast cells was ...
K, Banovac +4 more
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Cross-reactions of Class II Histocompatibility Antigens of Various Species
1986A major histocompatibility complex (MHC) has been demonstrated in all mammalian and avian species studied and in several fish and amphibian species. Interestingly, the MHC loci occur in a homologous linkage group in various species. Whether such conservation of a linkage group during the evolution of species is due to chance or is of functional ...
M. Pla, P. Ivanyi
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