Results 131 to 140 of about 46,167 (292)

COL1A1+ Epithelial Cells Orchestrate VEGFA‐VEGFR Signaling in Endometritis Revealed by Single‐Cell Analysis

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Single‐cell RNA‐seq of normal and endometritis endometrium shows reduced epithelial cells and fate divergence toward ferroptosis or ribosome/antigen‐presentation programs. COL1A1+ epithelial cells act as an AP‐1–driven hub that enhances VEGFA–VEGFR signaling and remodels the vascular microenvironment.
Chengzi Tian, Zaiyi Li
wiley   +1 more source

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders

open access: yesJCPP Advances, EarlyView.
Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser   +6 more
wiley   +1 more source

Impact of ethnicity, donor status and HLA matching on renal allograft survival: A single center study

open access: yesSaudi Journal of Kidney Diseases and Transplantation, 2009
The role of histocompatibility testing in renal transplantation is passing through an immense debate on its utility in predicting long-term graft survival.
Chelluri Lakshmi   +2 more
doaj  

Histocompatibility testing

open access: yes, 2002
Southeast Asian Journal of Tropical Medicine and Public Health33SUPPL.2112 ...
Chee, R.E.
core  

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella   +6 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao   +4 more
wiley   +1 more source

Genetic Testing

open access: yes, 2003
The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 13 July 2001.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2003.©The Trustee of the Wellcome Trust ...
CHRISTIE, DA, TANSEY, EM
core  

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys   +16 more
wiley   +1 more source

Massive Sampling Strategy for Antibody–Antigen Targets in CAPRI Round 55 With MassiveFold

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Massive sampling with AlphaFold2 improves protein–protein complex predictions. This has been shown during the last CASP15‐CAPRI blind prediction round by the AFsample tool. However, more difficult targets including antibody–antigen binding remain challenging. CAPRI Round 55 consisted of three antibody–antigen targets and one heterotrimer.
Nessim Raouraoua   +2 more
wiley   +1 more source

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