Results 61 to 70 of about 483,454 (329)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Comparison of CT- and MRI-Based Quantification of Tumor Heterogeneity and Vascularity for Correlations with Prognostic Biomarkers and Survival Outcomes: A Single-Center Prospective Cohort Study

Bioengineering, 2023
Background: Tumor heterogeneity and vascularity can be noninvasively quantified using histogram and perfusion analyses on computed tomography (CT) and magnetic resonance imaging (MRI).
Hyo-Young Kim, Min-Sun Bae, Bo-Kyoung Seo, Ji-Young Lee, Kyu-Ran Cho, Ok-Hee Woo, Sung-Eun Song, Jaehyung Cha   +7 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

A Local Discrete Feature Histogram for Point Cloud Feature Representation

Applied Sciences
Local feature descriptors are a critical problem in computer vision; the majority of current approaches find it difficult to achieve a balance between descriptiveness, robustness, compactness, and efficiency. This paper proposes the local discrete feature histogram (LDFH), a novel local feature descriptor, as a solution to this problem.
Linjing Jia, Cong Li, Guan Xi, Xuelian Liu, Da Xie, Chunyang Wang   +5 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Perfusion, Diffusion, Or Brain Tumor Barrier Integrity: Which Represents The Glioma Features Best?

Cancer Management and Research, 2019
Lin-Feng Yan,1,* Ying-Zhi Sun,1,* Sha-Sha Zhao,1,* Yu-Chuan Hu,1,* Yu Han,1 Gang Li,2 Xin Zhang,1 Qiang Tian,1 Zhi-Cheng Liu,1 Yang Yang,1 Hai-Yan Nan,1 Ying Yu,1 Qian Sun,1 Jin Zhang,1 Ping Chen,1 Bo Hu,1 Fei Li,3 Teng-Hui Han,3 Wen Wang,1 Guang-Bin ...
Yan LF, Sun YZ, Zhao SS, Hu YC, Han Y, Li G, Zhang X, Tian Q, Liu ZC, Yang Y, Nan HY, Yu Y, Sun Q, Zhang J, Chen P, Hu B, Li F, Han TH, Wang W, Cui GB   +19 more
doaj  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Nearest Neighbor For Histogram-based Feature Extraction

Procedia Computer Science, 2011
AbstractManual grading process of Fresh Fruit Bunch (FFB) leads to misconduct and human error while inspecting the right category of fruits for the purpose of oil palm production at the mill. It is extremely important to identify the degree of ripeness of FFB are at 95% level of confidence as mentioned by Malaysian Palm Oil Board (MPOB).
Mohamad, Fatma Susilawati, Abd. Manaf, Azizah, Chuprat, Suriayati   +2 more
openaire   +2 more sources

Deep Learning and Histogram-Based Grain Size Analysis of Images

Sensors
Grain size analysis is used to study grain size and distribution. It is a critical indicator in sedimentary simulation experiments (SSEs), which aids in understanding hydrodynamic conditions and identifying the features of sedimentary environments ...
Wei Wei, Xiaohong Xu, Guangming Hu, Yanlin Shao, Qing Wang   +4 more
doaj   +1 more source