Results 111 to 120 of about 207,989 (291)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

THE FORMATION OF HISTOLOGY AS AN INDEPENDENT SCIENTIFIC DISCIPLINE ON MEDICAL FACULTY OF THE IMPERIAL MOSCOW UNIVERSITY IN THE MIDDLE OF XIX CENTURY (1860–1891)

open access: yesСеченовский вестник, 2012
The paper gives a brief outline of the institutional and cognitive structure of university education and science in Russia as an example of the morphological sciences at the medical faculty of the Imperial Moscow University.
S. L. Kuznetsov, C. S. Ghadzhieva
doaj  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Protective Effects of the Essence and Aqueous Extract of Achillea millefolium and Vitamin E on Atrazine-induced Follicular Atresia in Rats

open access: yesJournal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Atrazine causes some biological effects including atresia in ovarian folicules. Essense and aqueous extract of Achillea milifolium and vitamin E are important due to prevention of atresia.
Shapour Hasanzadeh   +2 more
doaj  

Comparative analysis of human Mesenchymal Stromal Cells from Adipose Tissue and Dental Pulp: phenotypic characterization and secretome profiling

open access: yesBiology Direct
Background In tissue regeneration, as well as in post-traumatic recovery or in treating pathological alterations, mesenchymal stromal cells (MSCs) and their products for cell-free treatments are increasingly attractive and applicable.
Alessia Ventura   +17 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

PCOS women show significantly higher homocysteine level, independent to glucose and E2 level

open access: yesIranian Journal of Reproductive Medicine, 2016
Background: It is reasonable to think that some biochemical characteristics of follicular fluid (FF) surrounding the oocyte may play a critical role in determining the quality of oocyte and the subsequent potential needed to achieve fertilization and ...
Zahra Eskandari   +3 more
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Comparative Histology of Alfalfa and Clovers [PDF]

open access: yesBotanical Gazette, 1914
Perennial leguminous forage plants are growing in importance both for green feeding and for hay, and some of them, notably alfalfa, red and alsike clovers, are well adapted for grinding into meal. The work detailed in this paper was undertaken to facilitate the microscopic identification of the species named in mixed cattle foods.
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

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