Results 201 to 210 of about 1,714,596 (353)

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo   +7 more
wiley   +1 more source

The assessment for potential thyroid-mediated endocrine disruption in amphibians: Clarification on the use of new methods and on the interpretation of changes in thyroid histology. [PDF]

open access: yesEFSA J
European Food Safety Authority (EFSA)   +17 more
europepmc   +1 more source

Histology [PDF]

open access: yesPostgraduate Medical Journal, 1950
openaire   +1 more source

Clinical Evaluation of Cytology and Histology for Gastric Malignancy

open access: diamond, 1981
Hirofumi Kudoh   +6 more
openalex   +2 more sources

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

open access: yesAdvanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu   +14 more
wiley   +1 more source

Rat Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Promote the Proliferation, Invasion, and Metastasis and Inhibit Apoptosis of Colorectal Cancer Stem Cells

open access: yesStem Cells International
Yu Jing   +8 more
doaj   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang   +13 more
wiley   +1 more source

Anatomy and baseline histology of the hoof capsule, corium, and digital cushion in free-ranging southern giraffe (Giraffa giraffa). [PDF]

open access: yesPLoS One
Dadone L   +7 more
europepmc   +1 more source

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