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Histone Acetylation and Histone Deacetylation
2003In the resting cell, DNA is tightly compacted to prevent transcription factor accessibility. During activation of the cell, this compact inaccessible DNA is made available to DNA-binding proteins, thus allowing the induction of gene transcription (1 ,2). DNA is packaged into chromatin, a highly organized and dynamic protein-DNA complex. The fundamental
Peter J. Barnes +2 more
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2008
Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three ...
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Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three ...
openaire +3 more sources
Chromatin structure: a repeating unit of histones and DNA.
Science, 1974R. Kornberg
semanticscholar +1 more source
High resolution acrylamide gel electrophoresis of histones.
Archives of Biochemistry and Biophysics, 1969S. Panyim, R. Chalkley
semanticscholar +1 more source
Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis*
Critical Care Medicine, 2015Y. Alhamdi +9 more
semanticscholar +1 more source
HISTONE-HISTONE AND HISTONE-DNA INTERACTIONS IN CHROMATIN
1983Juan Ausio +3 more
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Extraction, purification and analysis of histones
Nature Protocols, 2007D. Shechter +4 more
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