Results 81 to 90 of about 787,346 (293)

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Multimodality Treatment for Early-Stage Hepatocellular Carcinoma: A Bridging Therapy for Liver Transplantation [PDF]

, 2012
Purpose: To evaluate the efficiency of a multimodality approach consisting of transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) as bridging therapy for patients with hepatocellular carcinoma (HCC) awaiting orthotopic liver
A. Peporte, Bloomston M, Blum HE, F. Bamberg, F.T. Kolligs, J.A. Al-Tubaikh, M. D’Anastasi, M. Rentsch, M.F. Reiser, Marin HL, Minami Y, N. Ashoori, P. Paprottka, R.T. Hoffmann, Rossi S, S. Siegert, T.F. Jakobs   +16 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A NOVEL DEEP LEARNING APPROACHES FOR MULTI-CLASS HISTOPATHOLOGICAL SUB-IMAGE CLASSIFICATION USING PRIOR KNOWLEDGE

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
Early diagnosis of breast cancer is critical for effective treatment and reducing mortality rates. Computer-aided diagnosis tools have become essential for identifying and diagnosing cancer in its initial stages. Convolutional neural networks (CNNs) have
Riyam Ali Yassin, Morteza Valizadeh, Alaa Hussein Abdulaal   +2 more
doaj   +1 more source

Arthritis Is Developed in Borrelia-Primed And -Infected Mice Deficient of Interleukin-17 [PDF]

, 2016
Interleukin-17 (IL-17) has been shown to participate in the development of Lyme arthritis in experimental mice. For example, neutralization of IL-17 with antibodies inhibits induction of arthritis in Borrelia-primed and -infected C57BL/6 wild-type mice ...
Kuo, Joseph, Munson, Erik, Nardelli, Dean T., Schell, Ronald F., Warner, Thomas F.   +4 more
core   +1 more source

Infections with Avian Pathogenic and Fecal Escherichia coli Strains Display Similar Lung Histopathology and Macrophage Apoptosis [PDF]

, 2012
The purpose of this study was to compare histopathological changes in the lungs of chickens infected with avian pathogenic (APEC) and avian fecal (Afecal) Escherichia coli strains, and to analyze how the interaction of the bacteria with avian ...
AD Kennedy, André Mendes Ribeiro Corrêa, Bernd Kaspers, C Ciraci, C Ciraci, C Ewers, CD Tyler, Christa Ewers, CM Dozois, David Driemeier, E-M Antão, E-M Antão, F de Pace, Fabiana Horn, G Li, GW Li, H Beug, H He, I Chouikha, J Dai, J Mast, JN Maina, Karl Dietrich Weyrauch, LB Matter, Lothar H. Wieler, M Bastiani, M Caza, M Dho, M Dho-Moulin, M Mellata, Markus M. Heimesaat, MC Vidotto, Nicolle Lima Barbieri, P Germon, RM Dwars, S Reese, SA Pourbakhsh, SA Pourbakhsh, Susanne Glodde, TJ Johnson, Y Gavrieli   +40 more
core   +3 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Presence and significance of Helicobacter spp. in the gastric mucosa of Portuguese dogs [PDF]

, 2015
Background: Non-Helicobacter pylori Helicobacters (NHPH) are also able to cause disease in humans. Dogs are a natural reservoir for many of these species. Close and intense human contact with animals has been identified as a risk factor and therefore, an
Alves, Odete, Amorim, Irina, Gärtner, Fátima, Haesebrouck, Freddy, Reis, Celso, Saraiva, Ana Laura, Smet, Annemieke, Taulescu, Marian, Teixeira, Silvia   +8 more
core   +3 more sources

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source