Results 241 to 250 of about 256,649 (274)

MMRNet: Ensemble deep learning models for predicting mismatch repair deficiency in endometrial cancer from histopathological images. [PDF]

Cell Rep Med
Liu LL, Jing BZ, Liu X, Li RG, Wan Z, Zhang JY, Ouyang XM, Kong QN, Kang XL, Wang DD, Chen HH, Zhao ZH, Liang HY, Huang MY, Zheng CY, Yang X, Zheng XY, Zhang XK, Wei LJ, Cao C, Gao HY, Luo RZ, Cai MY.   +22 more
europepmc   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Multimodal representations of transfer learning with snake optimization algorithm on bone marrow cell classification using biomedical histopathological images. [PDF]

Sci Rep
Tarmissi K, Alsamri J, Maashi M, Asiri MM, Yahya AE, Alkharashi A, Abdullah M, Obayya M.   +7 more
europepmc   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Vision Transformers for Low-Quality Histopathological Images: A Case Study on Squamous Cell Carcinoma Margin Classification. [PDF]

Diagnostics (Basel)
Park SY, Ayana G, Wako BD, Jeong KC, Yoon SD, Choe SW.   +5 more
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

GenAI synthesis of histopathological images from Raman imaging for intraoperative tongue squamous cell carcinoma assessment. [PDF]

Int J Oral Sci
Yan B, Wen Z, Xue L, Wang T, Liu Z, Long W, Li Y, Jing R.   +7 more
europepmc   +1 more source

Artificial intelligence based vision transformer application for grading histopathological images of oral epithelial dysplasia: a step towards AI-driven diagnosis. [PDF]

BMC Cancer
Hadilou M, Mahdavi N, Keykha E, Ghofrani A, Tahmasebi E, Arabfard M.   +5 more
europepmc   +1 more source

Deep learning model targeting cancer surrounding tissues for accurate cancer diagnosis based on histopathological images. [PDF]

J Transl Med
Li L, Geng Y, Chen T, Lin K, Xie C, Qi J, Wei H, Wang J, Wang D, Yuan Z, Wan Z, Li T, Luo Y, Niu D, Li J, Yu H.   +15 more
europepmc   +1 more source

Predicting Breast Cancer Relapse from Histopathological Images with Ensemble Machine Learning Models. [PDF]

Curr Oncol
Sahoo G, Nayak AK, Tripathy PK, Panigrahi A, Pati A, Sahu B, Mahanty C, Mallik S.   +7 more
europepmc   +1 more source