Results 111 to 120 of about 698,939 (333)

Trained Immunity Exacerbates Inflammatory Arthritis Progression via Promoting Synovial Fibroblast Ferroptotic Resistance

Advanced Science, EarlyView.
β‐glucan‐induced trained immunity reprograms macrophages toward hyperinflammation, exacerbating inflammatory arthritis. In a collagen‐induced arthritis model, trained macrophages intensify disease severity and confer ferroptosis resistance in synovial cells via IL‐1β/NAT10‐mediated FSP1 mRNA modification.
Haibo Su, Baoying Zhang, Qiudi Deng, Jiaxin Huang, Jinyu Feng, Yuan Fu, Yuejun Huang, Weikun Deng, YingJun Su, Huisheng Liu, Ning‐yi Shao, Zhenhui Zhang, Jianwei Dai   +12 more
wiley   +1 more source

Nanographene Oxide Attenuates Acute GVHD by Modulating Macrophage Polarization in a Xenogeneic Mouse Model

Advanced Science, EarlyView.
Nanographene oxide (NGO) attenuates graft‐versus‐host disease (GVHD) severity by inhibiting STAT1‐mediated M1 macrophage polarization and suppressing T‐cell activation. NGO‐primed macrophages (NGO‐Mac) further enhance regulatory T‐cell induction via IL‐10. Both NGO and NGO‐Mac therapies mitigate inflammation and immune pathology, offering cell‐free and
Aaron Yu, Hyun Sung Park, Dong‐Hoon Chae, Jae Han Park, Jiyoung Heo, Keonwoo Cho, Jiho Kim, Hyewon Lee, Sueyeon Jee, Chanwoo Kim, Soon Won Choi, Jaechul Ryu, Eun‐Hye Hur, Yunsuk Choi, Eun‐Ji Choi, Mi‐Kyung Oh, Hwa‐Yong Lee, Je‐Hwan Lee, Kyung‐Rok Yu   +18 more
wiley   +1 more source

Cutting out the middleman: measuring nuclear area in histopathology slides without segmentation

, 2016
The size of nuclei in histological preparations from excised breast tumors is predictive of patient outcome (large nuclei indicate poor outcome). Pathologists take into account nuclear size when performing breast cancer grading.
D Cireşan, DC Cireşan, EC Mommers, HR Roth, M Veta, M Veta, P Kronqvist   +6 more
core   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Immunohistochemical Detection of CD147 Expression in Adenocarcinoma of the Prostate: A Case-Control Study

Prostate Cancer
Prostate cancer is the most common noncutaneous malignancy among men worldwide, including in Sudan, where it represents a significant public health challenge.
Sara Suliman, Mona Ellaithi
doaj   +1 more source

Chapter Five. Systematic review results by biomarker classifications [PDF]

, 2016
5.1 Markers of Absorption and Permeability Overview 5.2 Markers of Absorption 5.3 Markers of Permeability 5.4 Markers of Digestion 5.5 Markers of Intestinal Inflammation and Intestinal Immune Activation 5.6 Markers of Systemic Inflammation and Systemic ...
Denno, Donna M, Musser, Christine A, Nelson, Zakia C, Tarr, Phillip I, VanBuskirk, Kelley M   +4 more
core   +1 more source

AI‐Assisted Detection of Early Gastric Cancer via Visualization of Mucosal Acidity Compromise During Endoscopy

Advanced Science, EarlyView.
An AI‐assisted SERS system is developed to rapidly and reliably detect early gastric cancer by visualizing gastric mucosal acidity, enhancing endoscopic differentiation, improving guidance for submucosal dissection, and reducing false‐positive diagnoses.
Huihui Yan, Zongkuo Li, Jing Zhao, Lei Su, Ziyi Jin, Weiyi Zhao, Rong Duan, Suhongrui Zhou, Lingling Wang, Jianshan Mao, Xinliang Lu, Weihao Gai, Yang Du, Qin Du, Cheng Fang, Yiming Zhao, Yan You, Jianting Cai, Cong Li   +18 more
wiley   +1 more source

Exposición crónica a hongos productores de aflatoxinas relacionada a daños hepáticos en chinchillas (chinchilla lanigera) destinadas a la producción de piel [PDF]

, 2013
Chinchilla pelt is a rare and expensive fur. Therefore, breeding these animals is a profitable activity. Confirmed acute cases of aflatoxin intoxication have been reported in Argentinean farms.
Bagnis, Guillermo, Cavaglieri, Lilia Reneé, Dalcero, Ana Maria, Gonzalez Pereyra, Maria Laura, Landa, Maria Florencia, Pena, Gabriela Alejandra, Rosa, Carlos Alberto da Rocha   +6 more
core  

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Expression of programmed death-ligand 1, IRF1 and CD8 T lymphocyte infiltration in a primary subset of breast cancer patients in Sudan

Journal of Taibah University Medical Sciences
الملخص: أهداف البحث: تهدف هذه الدراسة إلى الكشف عن تعبير بروتين ليجند 1 المبرمج للموت في أنسجة سرطان الثدي، مرتبطة بتعبيرات متنوعة لحالة الإستروجين، بالإضافة إلى تعبير عامل تنظيم الأنترفيرون الأول وتسلل اللمفاويات تي القاتلة المتعددة باستخدام المناعة ...
Shahenaz S. Salih, MSc, Mohammed S. Abdelaziz, Ph.D, Ibtehal M. Abdelhag, MSc, Altaf S. Mosad, MSc   +3 more
doaj   +1 more source