Results 231 to 240 of about 713,518 (369)

Multimorbidity and animal models

Animal Models and Experimental Medicine, EarlyView.
Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang, Yakun Ren, Xingjiu Yang, Mengyuan Li, Junxiu Liu, Xiaoyan Du, Wen Wang, Ran Gao   +7 more
wiley   +1 more source

Improving final diagnosis in paediatric posterior fossa tumours: Correlation and discrepancy between radiologic diagnosis, intraoperative surgeon's diagnosis, and histopathology. [PDF]

Pak J Med Sci
Khan MN, Khan A, Mehmood T, Khan A, Khan MS.   +4 more
europepmc   +1 more source

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

Animal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai, Xintao Zhang, Tingting Luo, Wenhan Chen, Chenyu Ma, Haihua Luo, Jinghua Liu, Jia Xu   +7 more
wiley   +1 more source

Comprehensive Profiling of Annexins in Neuromuscular Disorders Reveals a Unique Signature in Dysferlinopathy. [PDF]

Eur J Neurol
He QF, Lin YH, Zheng ZL, Zeng MH, Lin X, Liu XY, Kang-Yang, Zhang QI, Lin MT, Wang N, Wang ZQ, Lin F.   +11 more
europepmc   +1 more source

Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen, Wei Liu, Dan Zhou, Shuhua Liu, Yalun Guan, Zongyu Miao, Lei Cai, Xuejiao Li, Yunfeng Li, Zhongqiang Huang, Yi Jin, Ge Li, Yu Zhang   +12 more
wiley   +1 more source

Appropriateness of Histopathology Specimen Containers and Completeness of Laboratory Request Forms in Uganda: A Case of Mbarara Regional Referral Hospital, South Western Uganda. [PDF]

Sage Open Pathol
Mitala Y, Atwine R, Dratu R, Ishimwe D, Kitenda FN, Musayi J, Kasadha IK, Tumwesigye H, Naluzze V, Eloba S, Tumwesigire S, Birungi A, Ssenkumba B.   +12 more
europepmc   +1 more source

Challenges of modeling pristane‐induced lupus in non‐human primates

Animal Models and Experimental Medicine, EarlyView.
Systemic lupus erythematosus (SLE) in cynomolgus monkeys was modeled by two intraperitoneal injections of pristane at a dose of 3.5 mL/kg, administered at weeks 1 and 23. Serum samples from all monkeys that received pristane tested positive for antinuclear antibodies.
Elena Vladimirovna Vinogradova, Maria Alexandrovna Varavko, Yakov Yuryevich Ustyugov, Alexey Alexandrovich Aleksandrov, Dmitry Alexandrovich Khochenkov, Yulia Nikolaevna Linkova   +5 more
wiley   +1 more source

Contrast-Enhanced Mammography Versus Digital Mammography and Tomosynthesis in Dense Breasts: Diagnostic Accuracy and Impact on Surgical Planning in Multifocal and Multicentric Breast Carcinoma. [PDF]

Cureus
Malik M, Baneen Zahra U, Fayyaz M, Idrees RB, Abdullah I, Rashid Mirza Z, Aasim M.   +6 more
europepmc   +1 more source

PV-0316 Deep Learning Based Automatic Grading of Colon Cancer in Digitized Histopathology Images

, 2019
Siyuan Chen, Junhu Wang, Wenjie Hu, Z. Zhang, Mei Zhang, Mingze Xu, Da-Yo Huang, Wei Sheng   +7 more
openalex   +1 more source

Subacute Toxic Effects of Melastoma malabathricum Linn. Aqueous Leaf Extract on Liver and Kidney Histopathology of Rats [PDF]

, 2013
Caroline Manicam, Li Teng Khoo, Janna Ong Abdullah, Eusni Rahayu Moh, Zainina Seman, Chin Chin Sieo, Muhajir Hamid   +6 more
openalex   +1 more source