Results 71 to 80 of about 1,116,516 (283)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Moving Beyond: Lessons from Archaeology Southwest’s cyberSW 2.0 Tribal Working Group Initiative

Advances in Archaeological Practice
In 2021, the cultural heritage nonprofit organization Archaeology Southwest received a Human Networks and Data Science grant from the US National Science Foundation to update its long-running archaeological research database, cyberSW.
Shane Anton, Garrett Briggs, Wade Campbell, Shiloh Craig, Patrick Cruz, Adesbah Foguth, Lauren Toho-Murrow Haupt, Ritchie Sahneyah, April Sewequaptewa, Jeffrey J. Clark, Caitlynn Mayhew, Sarah Oas, Andre Takagi, Joshua Watts, Skylar Begay, Anastasia Walhovd, Ashleigh BigWolf Thompson   +16 more
doaj   +1 more source

CZY WAWEL MOŻNA NADBUDOWAĆ? REFLEKSJE NA TEMAT KLASYFIKACJI ZABYTKÓW

Ochrona Dziedzictwa Kulturowego, 2016
None of the legal acts applied in the Polish monument protection system, ranging from the Regency Council Decree of 1918 to the Act of 2003, allows for transforming historic monuments and sites.
Jacek Dąbrowski, Dariusz Jankowski
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Introduction: Heritage legislation and management

Built Heritage, 2022
James K. Reap
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

WARTOŚĆ ZABYTKOWA MIERZONA W METRACH. OCHRONA ZABYTKÓW W KONTEKŚCIE USTAWY O OCHRONIE ZABYTKÓW I OPIECE NAD ZABYTKAMI ORAZ PRAWA BUDOWLANEGO

Ochrona Dziedzictwa Kulturowego, 2016
This article explores the relations between the provisions of the Act on the Protection and Guardianship of Monuments and Sites and the Construction Law from the perspective of modern historic preservation.
Helena Jadwiszczok-Molencka
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Research on preservation and renewal strategies for historic districts under space syntax [PDF]

ITM Web of Conferences
Historic districts are an integral part of urban communities, and due to the unique nature of their living heritage, they face the contradiction between preservation and development, necessitating the identification of suitable renewal models and ...
Wang Yawen, Wang Yanjun
doaj   +1 more source