Results 51 to 60 of about 1,586 (260)

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Prevention and Control Strategies for Rainwater and Flood Disasters in Traditional Villages: A Concentrated Contiguous Zone Approach

Buildings
Traditional villages are vital repositories of China’s historical and cultural heritage. To enhance protection precision, this study develops a novel risk assessment framework integrating three dimensions: the natural environment, tangible heritage ...
Xiao Lv, Hongyi Lin, Zhe Chen
doaj   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

An investigation on the impact of urban renewal on historical and cultural elements of Dongguan Street based on a space syntax approach

Journal of Asian Architecture and Building Engineering
The present study investigates the urban design elements and image of the city. The effective growth is accompanied by continuous progress of urbanization, the issues in China’s urban renewal construction have gradually become apparent.
Shao Jing, Muhammad Hafeez Abdul Nasir, Yan Maoan, Sun Shixin   +3 more
doaj   +1 more source

Transformation of Silifke—A Historic Town in Anatolia in the Ottoman Period

Buildings
This article focuses on the Ottoman Period urban fabric of Silifke, a crucial historical town in Turkey. The aim of this paper is to develop a research framework for the transfer of cultural heritage and cultural continuity in multi-layered historical ...
Meltem Akyürek Algın, Şebnem Hoşkara
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Spatial Planning in Protected Areas: Conceptualization and a Multi-Criteria Compatibility Assessment Model Applied to Kozara National Park

Land
Cultural and natural heritage are increasingly framed as components of territorial governance rather than isolated conservation elements; yet, a structural gap persists between their strategic recognition in planning documents and their measurable ...
Neda Živak, Irena Medar-Tanjga, Branka Zolak Poljašević, Vukosava Čolić, Dijana Gvozden Sliško, Mitja Tanjga   +5 more
doaj   +1 more source

Cultuurhistorie en ruimtelijke kwaliteit van de historische binnenstad. Het geheugen van een straat als inspiratiebron

Bulletin KNOB, 2008
Until recently cultural planning was a term used to refer to a relatively new field of policy that had come into vogue since the Belvedere Policy Document.
Wim Hupperetz
doaj   +1 more source

Clarification of the Boundaries of Lands of Historical and Cultural Heritage and Determination of Their Protection Zones by Remote Sensing Methods

Land
Determining precise boundaries and protective zones for historical and cultural objects enables their effective preservation. This article presents the framework for establishing protective zones around historical and cultural heritage sites existing in Ukraine, using the example of the Citadel defensive complex located in Lviv (Ukraine).
Borys Chetverikov, Volodymyr Hlotov, Krzysztof Bakuła   +2 more
openaire   +2 more sources

Comparative Insights and Overlooked Factors of Interphase Chemistry in Alkali Metal‐Ion Batteries

Advanced Energy Materials, EarlyView.
This review presents a comparative analysis of Li‐, Na‐, and K‐ion batteries, focusing on the critical role of electrode–electrolyte interphases. It especially highlights overlooked aspects such as SEI/CEI misconceptions, binder effects, and self‐discharge relevance, emphasizing the limitations of current understanding and offering strategies for ...
Changhee Lee, Zachary T. Gossage, Shinichi Kumakura, Shinichi Komaba   +3 more
wiley   +1 more source