Results 51 to 60 of about 2,783 (246)

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Do We Care about Built Cultural Heritage? The Empirical Evidence Based on the Veneto House Market [PDF]

Italian historical buildings require urgent and costly maintenance and restoration works, but neither the local, nor the national public administrators can afford these expenditures. Nevertheless the built cultural heritage represent a unique resource of
Lucia Rotaris, Margaretha Breil, Valentina Zanatta, Paolo Rosato   +3 more
core  

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Conservation, Management and Variation of the Cultural Heritage Sites of Jericho [PDF]

, 2012
This thesis explores management, conservation and valorization issues and their impacts on the safeguarding and developing of the cultural heritage of Jericho with an aim of setting up proper management, conservation, and valorisation policies for better
Rjoob, Ahmed
core  

An investigation on the impact of urban renewal on historical and cultural elements of Dongguan Street based on a space syntax approach

Journal of Asian Architecture and Building Engineering
The present study investigates the urban design elements and image of the city. The effective growth is accompanied by continuous progress of urbanization, the issues in China’s urban renewal construction have gradually become apparent.
Shao Jing, Muhammad Hafeez Abdul Nasir, Yan Maoan, Sun Shixin   +3 more
doaj   +1 more source

Transformation of Silifke—A Historic Town in Anatolia in the Ottoman Period

Buildings
This article focuses on the Ottoman Period urban fabric of Silifke, a crucial historical town in Turkey. The aim of this paper is to develop a research framework for the transfer of cultural heritage and cultural continuity in multi-layered historical ...
Meltem Akyürek Algın, Şebnem Hoşkara
doaj   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Exploring 'Place' in Planning and Zoning Debates Across a Rural-Urban Gradient [PDF]

, 2006
Land use policy and zoning are examined here as socio-political forms of landscape creation. This study examined the human-place perspective of rural residents experiencing demographic and physical changes due to the influx of new populations and ...
Gartin, Meredith
core