Results 141 to 150 of about 43,776 (307)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 1928 Notes and Documents section for Volume 6, Number 2, June 1928. It includes a proposed amendment for the Oklahoma Historical Society's constitution, the minutes of the meeting of the Board of Directors of the Oklahoma Historical Society held on May 1 ...
Oklahoma Historical Society
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
, 2013 Top Stories Lincoln's Avenger: Boston Corbett Kansas Archeology Training Program Field School: June 1-16 Hail to the Chief Coming Soon! Furnishing Kansas Basic Archives Workshop At Our Historic Sites Edward S. Curtis Photographs: a Sacred Legacy Frontier
Kansas State Historical Society
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Effect of storytelling on learning about the institutionalization of Unified Health System: randomized controlled trial. [PDF]
Rev Bras EnfermSilva ÁDME +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Importance of Being Nice: An Institutionalist Analysis of French Preferences on the Future of Europe [PDF]
This article offers an institutionalist explanation of French preferences on the future of Europe from the Maastricht Treaty of 1992 through the Constitutional Treaty of 2004. It argues that the autonomous institutional logic of the constitution-drafting
Nicolas Jabko
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Revisiting the Definition and Recognition of Indigenous Peoples and Local Communities for Biodiversity Conservation. [PDF]
Ecol EvolAhammad R +3 more
europepmc +1 more source