Results 141 to 150 of about 4,440,268 (301)

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Actors and Vehicles of Architectural Criticism (8)

open access: yes, 2016
Antwerp Architectural Exhibitions as Critical Actor in Belgium 1883-1972 Ellen Van Impe Centre for Flemish Architectural Archives, Vlaamse Architectuur Instituut (Flanders Architecture Institute) During the last quarter of the nineteenth century, the ...
Mapping Architectural Criticism
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Architectural Criticism between Public Debate and Autonomous Discipline - Lecture (10)

open access: yes, 2016
American Debates around the Autonomy of Critique in Architecture, 1990-2004 Louis Martin Professor, Department of Art History, Université du Québec à Montréal (UQAM) In 1990, the art historian Sylvia Lavin objected to the emergence of an autonomous form ...
Mapping Architectural Criticism
core  

Ethical universality in medicine: A critical rational bioethics beyond cultural relativism. [PDF]

open access: yesBrain Spine
Samprón N   +5 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Architectural Criticism between Public Debate and Autonomous Discipline - Lecture (9)

open access: yes, 2016
Architectural Criticism on the Art Market: An American Debate, 1975-1985 Martin Hartung gta/D-ARCH/ETH Zurich, Columbia University When in spring 1975, with the informal exhibition Architectural Studies and Projects at the Museum of Modern Art in New ...
Mapping Architectural Criticism
core  

Home - About - Disclaimer - Privacy