Results 61 to 70 of about 4,440,268 (301)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Architectural Criticism between Public Debate and Autonomous Discipline (4)
, 2016 Fixing boundaries. Architecture and criticism at the onset of the 20th century Rute Figueiredo gta/D-ARCH/ETH Zurich, Director of the Site of Discourse Research Project (Lisbon University) During the last few years, there has been an increasing interest ...
Mapping Architectural Criticism
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
IN QUEST FOR THE PEARL - TREATMENT OF HISTORY IN HOW TO QUIET A VAMPIRE BY BORISLAV PEKIĆ
Истраживања, 2012 Connections between Konrad Rutkovski, the hero of Pekić’s How to Quiet a Vampire and Goethe’s Faust are revealed, among other things, in the criticism of science articulated by both characters.
Slobodan Vladušić
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
News : Workshop, Mapping Architectural Criticism in China
, 2018 The workshop Mapping Architectural Criticism in China was held at the Department of Architecture, Xi'an Jiaotong-Liverpool University on April 24, 2018. You can download the full programme of the workshop here.
Mapping Architectural Criticism
core
Ibn Sayyid al-Nas's Methodology in Criticizing Historical Narratives Based on the Book of Uyun al-Athar [PDF]
تاریخ نگری و تاریخ نگاریThis article aims to introduce and explain the methodology of Hafiz Abu al-Fath Ibn Sayyid al-Nas, an Andalusian historian and writer of the seventh century AH, in criticizing historical narratives based on the book Ayoun al-Athar fi al-Maghazi wa al ...
Sajad Dadfar, Ali Akbar Ahmadi
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source