Results 71 to 80 of about 2,562,923 (336)

Simulating Historical Flows And Connection. The Artistic Transfer During The 15th To 16th Century In The Iberian Peninsula. [PDF]

open access: yes, 2019
The Late Gothic period (fourteenth-sixteenth century) was a phase of transition in Europe – with social, political, economic and cultural changes. Within this framework, Europe was the scene of a significant amount of mobility of artists that in some way
Ferreira Lopes, Patricia
core   +1 more source

Historical GIS Research in Canada

open access: yesEcological Restoration, 2015
that reveals how seasonality affects their physical and chemical environments. Where there’s water, there’s life, and Antarctica is no exception. Laybourn-Parry and Wadham use their knowledge of Antarctic lake systems, often using their own research, to ...
S. Bower
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The Transport Revolution on Land and Sea: Farming, Fishing, and Railways in Great Britain, 1840-1914

open access: yesHoST, 2018
The introduction and expansion of rapid rail transportation in Great Britain helped transform sea fishing and make fresh fish a new commodity of mass consumption.
Schwartz Robert M.
doaj   +1 more source

Structural analyses of features in cultural landscapes based on historical cadastral maps and GIS [PDF]

open access: yes, 2005
A landscape may appear to be ancient and to contain old man-made structures even if this is not the whole truth. Structures are moved, removed, replaced and added over the years. New users introduce new land use and management regimes.
Domaas, Stein Tage
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Power Interactions in the Evolution of Urban Road Networks: A Case Study of Nanjing since the Ming Dynasty

open access: yesRedai dili
Power perspective is important for understanding how urban road networks operate, promote public participation, and improve operational efficiency. Taking Nanjing (1368—1978) as an example, a six-century historical geographic information dataset of the ...
Bai Xuefeng   +4 more
doaj   +1 more source

Geospatial analysis and living urban geometry [PDF]

open access: yes, 2010
This essay outlines how to incorporate morphological rules within the exigencies of our technological age. We propose using the current evolution of GIS (Geographical Information Systems) technologies beyond their original representational domain ...
A.B. Jacobs   +27 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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